ASAH2

Gene Symbol	ASAH2
Entrez Gene	56624
Alt Symbol	BCDase, HNAC1, LCDase, N-CDase, NCDase
Species	Human
Gene Type	protein-coding
Description	N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2
Other Description	N-acylsphingosine amidohydrolase 2|acylsphingosine deacylase 2|mitochondrial ceramidase|neutral ceramidase|neutral/alkaline ceramidase|non-lysosomal ceramidase
Swissprots	Q71ME6 Q5T1D5 Q9NR71 Q5SZP7 Q3KNU1 Q5SNT7 Q5SZP6
Accessions	AAL06061 EAW80435 EAW80436 Q9NR71 AF250847 AAF86240 AF449759 AAQ04667 BC107105 AAI07106 BG289059 XM_011539970 XP_011538272 XM_011539971 XP_011538273 XM_011539972 XP_011538274 XM_011539973 XP_011538275 XR_945787 NM_001143974 NP_001137446 NM_019893 NP_063946
Function	Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid at an optimal pH of 6.5-8.5. Acts as a key regulator of sphingolipid signaling metabolites by generating sphingosine at the cell surface. Acts as a repressor of apoptosis both by reducing C16-ceramide, thereby preventing ceramide-induced apoptosis, and generating sphingosine, a precursor of the antiapoptotic factor sphingosine 1-phosphate. Probably involved in the digestion of dietary sphingolipids in intestine by acting as a key enzyme for the catabolism of dietary sphingolipids and regulating the levels of bioactive sphingolipid metabolites in the intestinal tract. {ECO:0000269|PubMed:15946935, ECO:0000269|PubMed:16061940}.
Subcellular Location	Cell membrane {ECO:0000269|PubMed:15845354}; Single-pass type II membrane protein {ECO:0000269|PubMed:15845354}. Note=The neutral ceramidase soluble form is a secreted protein. According to PubMed:10781606, it is mitochondrial. However, they used a shorter form in its N- terminus, which may explain this localization which probably does not exist in vivo.
Tissue Specificity	Primarily expressed in the intestine (PubMed:17334805). Ubiquitously expressed with higher levels in kidney, skeletal muscle and heart (PubMed:10781606). According to PubMed:17334805, ubiquitous expression attributed to ASAH2 may be actually that of the paralog ASAH2B. {ECO:0000269|PubMed:10781606, ECO:0000269|PubMed:17334805}.
Top Pathways	Sphingolipid signaling pathway, Sphingolipid metabolism

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2, ELISA Kit - MBS9322854 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

N-Acylsphingosine Amidohydrolase 2 (ASAH2), ELISA Kit - MBS9312547 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.1 ng/ml. Range 1.56 ng/ml - 50 ng/ml.

N-Acylsphingosine Amidohydrolase 2 (ASAH2), ELISA Kit - MBS2025148 from MyBioSource Category ELISA Kit Prices $380.00, $565.00, $765.00, $3,130.00, $5,670.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity Typically less than 0.31ng/mL. Range 0.781-50ng/mL

ELISA Kit for N-Acylsphingosine Amidohydrolase 2 (ASAH2) - SEE689Hu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.28ng/mL. Range 0.781-50ng/mL The standard curve concentrations used for the ELISA’s were 50ng/mL, 25ng/mL, 12.5ng/mL, 6.25ng/mL, 3.125ng/mL, 1.563ng/mL, 0.781ng/mL

ELISA Kit for N-Acylsphingosine Amidohydrolase 2 (ASAH2) - SEE689Hu from Cloud-clone Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.28ng/mL. Range 0.781-50ng/mL The standard curve concentrations used for the ELISA's were 50ng/mL, 25ng/mL, 12.5ng/mL, 6.25ng/mL, 3.125ng/mL, 1.563ng/mL, 0.781ng/mL

Human N-Acylsphingosine Amidohydrolase 2 (ASAH2) ELISA Kit - EKU08474 from Biomatik Category ELISA Kit Prices $735.00, $3,234.00, $5,880.00 Sizes 96 t, 5x96t, 10x96t Sensitivity 0.31 ng/mL Range 0.781-50 ng/mL

Human N-Acylsphingosine Amidohydrolase 2 ELISA Kit - abx156834 from Abbexa Category ELISA Kit Range 0.781 ng/ml - 50 ng/ml

Human ASAH2 ELISA Kit (Sandwich ELISA) - LS-F25469 from LifeSpan Bioscience Category ELISA Kit Prices $780.00 Sizes 1 plate Sensitivity 0.31 ng/ml Range 0.781-50 ng/ml

Custom Human ASAH2/Neutral Ceramidase ELISA - ELH-ASAH2-1 from RayBiotech Category ELISA Kit Prices $627.00, $1,128.60, $2,508.00 Sizes 1 plate kit, 2 plate kit, 5 plate kit

Custom Human ASAH2 ELISA Kit - orb384472 from Biorbyt Category ELISA Kit Prices $1,411.00, $2,448.00, $5,321.00 Sizes 96 assays, 192 assays, 480 assays

Human ASAH2 ELISA Kit - E025649 from Biobool Category ELISA Kit Sensitivity Typically less than 0.31ng/mL.

ASAH2 ELISA Kit (Human) (OKCD01831) - OKCD01831 from Aviva Systems Biology Category ELISA Kit Prices $545.00 Sizes 96 wells Sensitivity < 0.31 ng/mL Range 0.781 - 50 ng/mL

anti-ASAH2 antibody - ARG57406 from Arigo Biolaboratories Category ELISA Kit

N-Acylsphingosine Amidohydrolase 2 (ASAH2), ELISA Kit - MBS9391159 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

N-Acylsphingosine Amidohydrolase 2 (ASAH2), ELISA Kit - MBS9391167 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Neutral Ceramidase (ASAH2), ELISA Kit - MBS9391179 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Neutral Ceramidase (ASAH2), ELISA Kit - MBS9391187 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

N-Acylsphingosine Amidohydrolase 2 (ASAH2), ELISA Kit - MBS9391152 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Neutral Ceramidase (ASAH2), ELISA Kit - MBS9391172 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

N-Acylsphingosine Amidohydrolase 2 (ASAH2), ELISA Kit - MBS9391155 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Neutral Ceramidase (ASAH2), ELISA Kit - MBS9391175 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

N-Acylsphingosine Amidohydrolase 2 (ASAH2), ELISA Kit - MBS9391153 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Neutral Ceramidase (ASAH2), ELISA Kit - MBS9391173 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

N-Acylsphingosine Amidohydrolase 2 (ASAH2), ELISA Kit - MBS9391154 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Neutral Ceramidase (ASAH2), ELISA Kit - MBS9391174 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

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