| Gene Symbol | ASAH2 |
|---|---|
| Entrez Gene | 56624 |
| Alt Symbol | BCDase, HNAC1, LCDase, N-CDase, NCDase |
| Species | Human |
| Gene Type | protein-coding |
| Description | N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2 |
| Other Description | N-acylsphingosine amidohydrolase 2|acylsphingosine deacylase 2|mitochondrial ceramidase|neutral ceramidase|neutral/alkaline ceramidase|non-lysosomal ceramidase |
| Swissprots | Q71ME6 Q5T1D5 Q9NR71 Q5SZP7 Q3KNU1 Q5SNT7 Q5SZP6 |
| Accessions | AAL06061 EAW80435 EAW80436 Q9NR71 AF250847 AAF86240 AF449759 AAQ04667 BC107105 AAI07106 BG289059 XM_011539970 XP_011538272 XM_011539971 XP_011538273 XM_011539972 XP_011538274 XM_011539973 XP_011538275 XR_945787 NM_001143974 NP_001137446 NM_019893 NP_063946 |
| Function | Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid at an optimal pH of 6.5-8.5. Acts as a key regulator of sphingolipid signaling metabolites by generating sphingosine at the cell surface. Acts as a repressor of apoptosis both by reducing C16-ceramide, thereby preventing ceramide-induced apoptosis, and generating sphingosine, a precursor of the antiapoptotic factor sphingosine 1-phosphate. Probably involved in the digestion of dietary sphingolipids in intestine by acting as a key enzyme for the catabolism of dietary sphingolipids and regulating the levels of bioactive sphingolipid metabolites in the intestinal tract. {ECO:0000269|PubMed:15946935, ECO:0000269|PubMed:16061940}. |
| Subcellular Location | Cell membrane {ECO:0000269|PubMed:15845354}; Single-pass type II membrane protein {ECO:0000269|PubMed:15845354}. Note=The neutral ceramidase soluble form is a secreted protein. According to PubMed:10781606, it is mitochondrial. However, they used a shorter form in its N- terminus, which may explain this localization which probably does not exist in vivo. |
| Tissue Specificity | Primarily expressed in the intestine (PubMed:17334805). Ubiquitously expressed with higher levels in kidney, skeletal muscle and heart (PubMed:10781606). According to PubMed:17334805, ubiquitous expression attributed to ASAH2 may be actually that of the paralog ASAH2B. {ECO:0000269|PubMed:10781606, ECO:0000269|PubMed:17334805}. |
| Top Pathways | Sphingolipid signaling pathway, Sphingolipid metabolism |
ASAH2 Antibody Blocking Peptide - LS-E5221 from LifeSpan Bioscience
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ASAH2 Antibody Blocking Peptide - LS-E30547 from LifeSpan Bioscience
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ASAH2-Antibody-C-term-Blocking-Peptide - BP17664b from Abgent, a WuXi AppTec company
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Recombinant Human ASAH2, CF - 3557-AH-010 from R&D Systems
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ASAH2 Blocking Peptide - 33R-10941 from Fitzgerald
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Neutral ceramidase / ASAH2 Control Peptide - AP30083CP-N from Acris Antibodies
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ASAH2 Peptide - 4743P from ProSci
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Recombinant Human N-Acylsphingosine Amidohydrolase (non-lysosomal ceramidase) 2, His-tagged - ASAH2-582H from Creative Biomart
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Recombinant Human ASAH2, His-tagged - ASAH2-284H from Creative Biomart
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Recombinant N-Acylsphingosine Amidohydrolase 2 (ASAH2) - RPE689Hu01 from Uscn Life Science Inc.
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Recombinant N-Acylsphingosine Amidohydrolase 2 (ASAH2) - RPE689Hu01 from Cloud-clone
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Recombinant Human Neutral ceramidase(ASAH2) - CSB-YP865115HU CSB-EP865115HU CSB-BP865115HU CSB-MP865115HU from Cusabio
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ASAH2 Blocking Peptide - 3828BP-50 from Biovision
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Recombinant Human ASAH2 Protein, CF - 3557-AH from R&D Systems
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ASAH2 Protein - abx164506 from Abbexa
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ASAH2, Peptide - MBS843814 from MyBioSource
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ASAH2/N-acylsphingosine Amidohydrolase-2 Recombinant Protein Antigen - NBP2-49326PEP from Novus Biologicals
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ASAH2 Peptide, Human - M34GP01004H from Creative Peptides
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neutral ceramidase (ASAH2), Recombinant Protein - MBS1018537 from MyBioSource
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Recombinant Mouse ASAH2 Protein, CF - 3558-AH from Novus Biologicals
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Recombinant Human ASAH2 Protein, CF - 3557-AH from Novus Biologicals
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