| Gene Symbol |
ASAH2
|
| Entrez Gene |
56624
|
| Alt Symbol |
BCDase, HNAC1, LCDase, N-CDase, NCDase
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2
|
| Other Description |
N-acylsphingosine amidohydrolase 2|acylsphingosine deacylase 2|mitochondrial ceramidase|neutral ceramidase|neutral/alkaline ceramidase|non-lysosomal ceramidase
|
| Swissprots |
Q71ME6 Q5T1D5 Q9NR71 Q5SZP7 Q3KNU1 Q5SNT7 Q5SZP6
|
| Accessions |
AAL06061 EAW80435 EAW80436 Q9NR71 AF250847 AAF86240 AF449759 AAQ04667 BC107105 AAI07106 BG289059 XM_011539970 XP_011538272 XM_011539971 XP_011538273 XM_011539972 XP_011538274 XM_011539973 XP_011538275 XR_945787 NM_001143974 NP_001137446 NM_019893 NP_063946
|
| Function |
Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid at an optimal pH of 6.5-8.5. Acts as a key regulator of sphingolipid signaling metabolites by generating sphingosine at the cell surface. Acts as a repressor of apoptosis both by reducing C16-ceramide, thereby preventing ceramide-induced apoptosis, and generating sphingosine, a precursor of the antiapoptotic factor sphingosine 1-phosphate. Probably involved in the digestion of dietary sphingolipids in intestine by acting as a key enzyme for the catabolism of dietary sphingolipids and regulating the levels of bioactive sphingolipid metabolites in the intestinal tract. {ECO:0000269|PubMed:15946935, ECO:0000269|PubMed:16061940}.
|
| Subcellular Location |
Cell membrane {ECO:0000269|PubMed:15845354}; Single-pass type II membrane protein {ECO:0000269|PubMed:15845354}. Note=The neutral ceramidase soluble form is a secreted protein. According to PubMed:10781606, it is mitochondrial. However, they used a shorter form in its N- terminus, which may explain this localization which probably does not exist in vivo.
|
| Tissue Specificity |
Primarily expressed in the intestine (PubMed:17334805). Ubiquitously expressed with higher levels in kidney, skeletal muscle and heart (PubMed:10781606). According to PubMed:17334805, ubiquitous expression attributed to ASAH2 may be actually that of the paralog ASAH2B. {ECO:0000269|PubMed:10781606, ECO:0000269|PubMed:17334805}.
|
| Top Pathways |
Sphingolipid signaling pathway, Sphingolipid metabolism
|