PYDC1

Gene Symbol PYDC1
Entrez Gene 260434
Alt Symbol ASC2, POP1, PYC1
Species Human
Gene Type protein-coding
Description PYD (pyrin domain) containing 1
Other Description PAAD-only protein 1|pyrin domain-containing protein 1|pyrin-only protein 1
Swissprots B2R8L4 Q8WXC3 Q8NFP8
Accessions EAW52147 Q8WXC3 AF086332 AF454669 AAL58439 AF467809 AAN03745 AK313418 BAG36211 AY163727 AAO23114 BC105033 AAI05034 BC105035 AAI05036 NM_152901 NP_690865
Function Associates with apoptosis-associated specklike protein containing a CARD domain (ASC) and modulates its ability to collaborate with pyrin and cryopyrin in NF-kappa-B and pro- caspase-1 activation. Suppresses kinase activity of NF-kappa-B inhibitor kinase (IKK) complex, expression of NF-kappa-B inducible genes and inhibits NF-kappa-B activation by cytokines and LPS. {ECO:0000269|PubMed:12656673}.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:12656673}.
Tissue Specificity Predominantly expressed in monocytes, macrophages and granulocytes. {ECO:0000269|PubMed:12656673}.
Top Pathways NOD-like receptor signaling pathway

ASC2 (C-14) - sc-249968 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

ASC2 (FL-89) - sc-98694 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
ASC2 (FL-89): sc-98694. Western blot analysis of ASC2 expression in human lymph node tissue extract.

Anti-ASC2 antibody - ab171562 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-ASC2 antibody (ab171562) at 1/100 dilution + NCI-H292 cell line lysate at 35 µg

Anti-ASC2 antibody - ab47092 from Abcam

Prices $370.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-ASC2 antibody (ab47092) at 1/2000 dilutionLane 1 : HEK-293 cells transiently transfected with plasmid encoding ASC2Lane 2 : HEK-293 cells transiently transfected with plasmid encoding POP1Lane 3 : HEK-293 cells transiently transfected with a negative control plasmid

Anti-PYDC1 Antibody (aa12-42, AP) - LS-C239637 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PYDC1 Antibody (aa12-42, APC) - LS-C239638 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PYDC1 Antibody (aa12-42, Biotin) - LS-C239639 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PYDC1 Antibody - LS-C144124 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

Anti-PYDC1 Antibody (aa12-42, Azide-free, HRP) - LS-C248591 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PYDC1 Antibody (aa12-42, PE) - LS-C239642 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PYDC1 Antibody (aa12-42, FITC) - LS-C239641 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PYDC1 Antibody (aa12-42) - LS-C324444 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PYDC1 Antibody (clone 11C3) - LS-C338781 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 11C3
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY PYDC1 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-PYDC1.

Anti-PYDC1 Antibody (clone 1C5) - LS-C338790 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1C5
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY PYDC1 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-PYDC1.

Anti-PYDC1 Antibody (clone 2G7) - LS-C338801 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 2G7
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY PYDC1 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-PYDC1.

Anti-PYDC1 Antibody (aa12-42) - LS-C158773 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
PYDC1 Antibody western blot of NCI-H292 cell line lysates (35 ug/lane). The PYDC1 antibody detected the PYDC1 protein (arrow).

Anti-PYDC1 Antibody (clone 9C10) - LS-C338756 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 9C10
IHC of paraffin-embedded Human prostate tissue using anti-PYDC1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120°C for 3min).

Anti-PYDC1 Antibody (clone 7A2) - LS-C338806 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 7A2
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY PYDC1 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-PYDC1.

Anti-PYDC1 Antibody (N-Terminus) - LS-C345107 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot of PYDC1 Antibody with human Lymph Node Tumor lysate.

Anti-PYDC1 Antibody (clone 9E12) - LS-C338791 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 9E12
IHC of paraffin-embedded Adenocarcinoma of Human colon tissue using anti-PYDC1 mouse monoclonal antibody. (heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120°C for 3min).

Anti-PYDC1 Antibody (clone 5D12) - LS-C338784 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 5D12
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY PYDC1 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-PYDC1.

Anti-PYDC1 Antibody (clone 1A4) - LS-C338789 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1A4
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY PYDC1 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-PYDC1.

ANTI-PYDC1 (CENTER) antibody produced in rabbit - SAB1302029 from Sigma-Aldrich

Prices $326.50
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-PYDC1 (Center): <B>Cat. No. SAB1302029</B>: PYDC1 Antibody (Center) western blot analysis in NCI-H292 cell line lysates (35 μg/lane).

PYDC1 Antibody - N-terminal region (ARP55560_P050) - ARP55560_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

PYDC1-Antibody-Center - AP13124c from Abgent, a WuXi AppTec company

Prices $99.00, $295.00
Sizes 80 µl, 400 µl
Host Rabbit
Clonality Polyclonal
PYDC1 Antibody (Center) (Cat. #AP13124c) western blot analysis in NCI-H292 cell line lysates (35ug/lane).This demonstrates the PYDC1 antibody detected the PYDC1 protein (arrow).
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