| Gene Symbol |
PYDC1
|
| Entrez Gene |
260434
|
| Alt Symbol |
ASC2, POP1, PYC1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
PYD (pyrin domain) containing 1
|
| Other Description |
PAAD-only protein 1|pyrin domain-containing protein 1|pyrin-only protein 1
|
| Swissprots |
B2R8L4 Q8WXC3 Q8NFP8
|
| Accessions |
EAW52147 Q8WXC3 AF086332 AF454669 AAL58439 AF467809 AAN03745 AK313418 BAG36211 AY163727 AAO23114 BC105033 AAI05034 BC105035 AAI05036 NM_152901 NP_690865
|
| Function |
Associates with apoptosis-associated specklike protein containing a CARD domain (ASC) and modulates its ability to collaborate with pyrin and cryopyrin in NF-kappa-B and pro- caspase-1 activation. Suppresses kinase activity of NF-kappa-B inhibitor kinase (IKK) complex, expression of NF-kappa-B inducible genes and inhibits NF-kappa-B activation by cytokines and LPS. {ECO:0000269|PubMed:12656673}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:12656673}.
|
| Tissue Specificity |
Predominantly expressed in monocytes, macrophages and granulocytes. {ECO:0000269|PubMed:12656673}.
|
| Top Pathways |
NOD-like receptor signaling pathway
|