PYDC1

Gene Symbol	PYDC1
Entrez Gene	260434
Alt Symbol	ASC2, POP1, PYC1
Species	Human
Gene Type	protein-coding
Description	PYD (pyrin domain) containing 1
Other Description	PAAD-only protein 1|pyrin domain-containing protein 1|pyrin-only protein 1
Swissprots	B2R8L4 Q8WXC3 Q8NFP8
Accessions	EAW52147 Q8WXC3 AF086332 AF454669 AAL58439 AF467809 AAN03745 AK313418 BAG36211 AY163727 AAO23114 BC105033 AAI05034 BC105035 AAI05036 NM_152901 NP_690865
Function	Associates with apoptosis-associated specklike protein containing a CARD domain (ASC) and modulates its ability to collaborate with pyrin and cryopyrin in NF-kappa-B and pro- caspase-1 activation. Suppresses kinase activity of NF-kappa-B inhibitor kinase (IKK) complex, expression of NF-kappa-B inducible genes and inhibits NF-kappa-B activation by cytokines and LPS. {ECO:0000269|PubMed:12656673}.
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:12656673}.
Tissue Specificity	Predominantly expressed in monocytes, macrophages and granulocytes. {ECO:0000269|PubMed:12656673}.
Top Pathways	NOD-like receptor signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• Cell/Tissue/Blood Products

PYDC1 overexpression lysate - LY407263 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

PYDC1 293 Cell Lysate - 404174 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

ASC2 Overexpression Lysate (Native) - NBL1-15020 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

PYDC1 Over-expression Lysate Product - GWB-810339 from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

Panoply™ Human PYDC1 Knockdown Stable Cell Line - CSC-DC012778 from Creative biogene Category Cell Line Species Human

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