| Gene Symbol |
MAP3K2
|
| Entrez Gene |
10746
|
| Alt Symbol |
MEKK2, MEKK2B
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
mitogen-activated protein kinase kinase kinase 2
|
| Other Description |
MAP/ERK kinase kinase 2|MAPK/ERK kinase kinase 2|MEK kinase 2|MEKK 2
|
| Swissprots |
Q53QL9 Q59GZ6 Q53S75 Q9NYK3 Q8NC32 Q9Y2U5 B9EG87
|
| Accessions |
AAY15043 AAY15070 CAJ15104 EAW95315 EAW95316 Q9Y2U5 AB208963 BAD92200 AF111105 AAD28547 AF239798 AAF63496 AI760702 AK027345 BAB55050 AK074577 AK075004 BAC11348 AK093893 AK315007 BC065755 AAH65755 BC136293 AAI36294 BM470563 BQ423724 W07290 NM_006609 NP_006600
|
| Function |
Component of a protein kinase signal transduction cascade. Regulates the JNK and ERK5 pathways by phosphorylating and activating MAP2K5 and MAP2K7 (By similarity). Plays a role in caveolae kiss-and-run dynamics. {ECO:0000250, ECO:0000269|PubMed:10713157, ECO:0000269|PubMed:16001074}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:15075238}. Nucleus {ECO:0000269|PubMed:15075238}. Note=Upon EGF stimulation, translocates into the nucleus.
|
| Top Pathways |
Gap junction, GnRH signaling pathway, MAPK signaling pathway
|
![Western Blot: MEKK2 Overexpression Lysate (Adult Normal) [NBL1-12854] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for MEKK2.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/7804_MEKK2%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-12854-img0002.jpg)