MAP3K2

Gene Symbol MAP3K2
Entrez Gene 10746
Alt Symbol MEKK2, MEKK2B
Species Human
Gene Type protein-coding
Description mitogen-activated protein kinase kinase kinase 2
Other Description MAP/ERK kinase kinase 2|MAPK/ERK kinase kinase 2|MEK kinase 2|MEKK 2
Swissprots Q53QL9 Q59GZ6 Q53S75 Q9NYK3 Q8NC32 Q9Y2U5 B9EG87
Accessions AAY15043 AAY15070 CAJ15104 EAW95315 EAW95316 Q9Y2U5 AB208963 BAD92200 AF111105 AAD28547 AF239798 AAF63496 AI760702 AK027345 BAB55050 AK074577 AK075004 BAC11348 AK093893 AK315007 BC065755 AAH65755 BC136293 AAI36294 BM470563 BQ423724 W07290 NM_006609 NP_006600
Function Component of a protein kinase signal transduction cascade. Regulates the JNK and ERK5 pathways by phosphorylating and activating MAP2K5 and MAP2K7 (By similarity). Plays a role in caveolae kiss-and-run dynamics. {ECO:0000250, ECO:0000269|PubMed:10713157, ECO:0000269|PubMed:16001074}.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:15075238}. Nucleus {ECO:0000269|PubMed:15075238}. Note=Upon EGF stimulation, translocates into the nucleus.
Top Pathways Gap junction, GnRH signaling pathway, MAPK signaling pathway

MEK kinase-2 CRISPR/Cas9 KO Plasmid (h) - sc-403653 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

MEK kinase-2 HDR Plasmid (h) - sc-403653-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MEK kinase-2 Double Nickase Plasmid (h) - sc-403653-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MEK kinase-2 Double Nickase Plasmid (h2) - sc-403653-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MEK kinase-2 CRISPR Activation Plasmid (h) - sc-403653-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

MEK kinase-2 CRISPR Activation Plasmid (h2) - sc-403653-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

MEK kinase-2 Lentiviral Activation Particles (h) - sc-403653-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MEK kinase-2 Lentiviral Activation Particles (h2) - sc-403653-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MEK kinase-2 siRNA (h) - sc-35900 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MEK kinase-2 shRNA Plasmid (h) - sc-35900-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MEK kinase-2 shRNA (h) Lentiviral Particles - sc-35900-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU081351 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

MISSION® siRNA - SIHK1143 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 0.25 nmol

MISSION® siRNA - SIHK1142 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 0.25 nmol

MISSION® siRNA - SIHK1141 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 0.25 nmol

CompoZr® Knockout ZFN Kit - CKOZFN12991 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND12991 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MAP3K2 siRNA (Human) - CRH7323 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

MEKK2 RNAi - H00010746-R03 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

shRNA set against Human MAP3K2 (NM_006609.4) - SHH337687 from Creative biogene

Category siRNA
Species Reactivities Human

MAP3K2 shRNA Plasmid (Human) - CHH7323 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human
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