MAP3K2

Gene Symbol	MAP3K2
Entrez Gene	10746
Alt Symbol	MEKK2, MEKK2B
Species	Human
Gene Type	protein-coding
Description	mitogen-activated protein kinase kinase kinase 2
Other Description	MAP/ERK kinase kinase 2\|MAPK/ERK kinase kinase 2\|MEK kinase 2\|MEKK 2
Swissprots	Q53QL9 Q59GZ6 Q53S75 Q9NYK3 Q8NC32 Q9Y2U5 B9EG87
Accessions	AAY15043 AAY15070 CAJ15104 EAW95315 EAW95316 Q9Y2U5 AB208963 BAD92200 AF111105 AAD28547 AF239798 AAF63496 AI760702 AK027345 BAB55050 AK074577 AK075004 BAC11348 AK093893 AK315007 BC065755 AAH65755 BC136293 AAI36294 BM470563 BQ423724 W07290 NM_006609 NP_006600
Function	Component of a protein kinase signal transduction cascade. Regulates the JNK and ERK5 pathways by phosphorylating and activating MAP2K5 and MAP2K7 (By similarity). Plays a role in caveolae kiss-and-run dynamics. {ECO:0000250, ECO:0000269\|PubMed:10713157, ECO:0000269\|PubMed:16001074}.
Subcellular Location	Cytoplasm {ECO:0000269\|PubMed:15075238}. Nucleus {ECO:0000269\|PubMed:15075238}. Note=Upon EGF stimulation, translocates into the nucleus.
Top Pathways	Gap junction, GnRH signaling pathway, MAPK signaling pathway

MEK kinase-2 (N-19) - sc-1088 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Rabbit
Clonality	Polyclonal

MEK kinase-2 (N-19): sc-1088. Western blot analysis of MEK kinase-2 expression in MCF7 (A), Jurkat (B), BJAB (C), Ramos (D) and K-562 (E) whole cell lysates.

MEK kinase-2 (C-18) - sc-1089 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Rabbit
Clonality	Polyclonal

MEK kinase-2 (C-18): sc-1089. Western blot analysis of MEK kinase-2 expression in K-562 (A) and Ramos (B) whole cell lysates.

MEK kinase-2 (H-80) - sc-28768 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Rabbit
Clonality	Polyclonal

Anti-MEKK2 antibody - ab199168 from Abcam

Prices	$376.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Immunohistochemical analysis of paraffin-embedded Human thyroid cancer tissue labeling MEKK2 with ab199168 at 1/15 dilution.

Anti-MEKK2 antibody - ab116348 from Abcam

Prices	$376.00
Sizes	400 µl
Host	Rabbit
Clonality	Polyclonal

All lanes : Anti-MEKK2 antibody (ab116348) at 1/100 dilutionLane 1 : 293 cell lysates, non-transfectedLane 2 : 293 cell lysates, MEKK2 transfected Lysates/proteins at 2 µg per lane.

Anti-MEKK2 antibody - ab125223 from Abcam

Prices	$376.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

All lanes : Anti-MEKK2 antibody (ab125223) at 1 µg/mlLane 1 : Rat brain tissue lysateLane 2 : Rat testicular tissue lysateLane 3 : Rat lung tissue lysate

Anti-MEKK2 antibody [4B4] - ab119884 from Abcam

Host	Mouse
Clonality	Monoclonal
Clone	4B4

Anti-MEKK2 antibody [4B4] (ab119884) at 1/500 dilution + MEKK2 recombinant protein

Anti-MEKK2 antibody [EP550Y] - ab40805 from Abcam

Prices	$379.00
Sizes	100 µl
Host	Rabbit
Clonality	Monoclonal
Clone	EP550Y

Anti-MEKK2 antibody [EP550Y] (ab40805) at 1/1000 dilution + Hela cell lysate at 10 µg

Anti-MEKK2 antibody [EP626Y] - ab33918 from Abcam

Prices	$401.00
Sizes	100 µl
Host	Rabbit
Clonality	Monoclonal
Clone	EP626Y

Anti-MEKK2 antibody [EP626Y] (ab33918) at 1/50000 dilution + Jurkat cell lysate

Anti-MAP3K2 / MEKK2 Antibody (aa14-43, APC) - LS-C223189 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-MAP3K2 / MEKK2 Antibody (aa14-43, AP) - LS-C223190 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-MAP3K2 / MEKK2 Antibody (aa14-43, PE) - LS-C223194 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-MAP3K2 / MEKK2 Antibody (aa14-43, Biotin) - LS-C223191 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-MAP3K2 / MEKK2 Antibody (aa14-43, FITC) - LS-C223192 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-MAP3K2 / MEKK2 Antibody (aa14-43, Azide-free, HRP) - LS-C223193 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-MAP3K2 / MEKK2 Antibody (aa125-175) - LS-C288918 from LifeSpan Bioscience

Prices	$375.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Anti-MAP3K2 / MEKK2 Antibody (aa1-50) - LS-C47356 from LifeSpan Bioscience

Prices	$335.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Western blot of human MEKK2in human liver cell lysate in the 1) absence and 2) presence of immunizing peptide using antibody at2 ug/ml.

Anti-MAP3K2 / MEKK2 Antibody (aa1-50) - LS-C288919 from LifeSpan Bioscience

Prices	$375.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Anti-MAP3K2 / MEKK2 Antibody (aa13-43) - LS-C322834 from LifeSpan Bioscience

Prices	$345.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-MAP3K2 / MEKK2 Antibody - LS-C340922 from LifeSpan Bioscience

Prices	$385.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-MAP3K2 / MEKK2 Antibody (aa146-195) - LS-C81354 from LifeSpan Bioscience

Prices	$365.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

MCF7 cell lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 12%.

Anti-MAP3K2 / MEKK2 Antibody (aa606-619) - LS-C312656 from LifeSpan Bioscience

Prices	$305.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

WB of MAP3K2 / MEKK2 antibody. All lanes: Anti-MAP3K2 at 0.5ug/ml. Lane 1: Rat Brain Tissue Lysate at 40ug. Lane 2: Rat Testis Tissue Lysate at 40ug. Lane 3: Rat Lung Tissue Lysate at 40ug. Predicted bind size: 70KD. Observed bind size: 70KD.

Anti-MAP3K2 / MEKK2 Antibody - LS-C332198 from LifeSpan Bioscience

Prices	$305.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

Western blot analysis of extracts of HeLa cell line, using MAP3K2 antibody.

Anti-MAP3K2 / MEKK2 Antibody (C-Terminus, clone EP550Y) - LS-C49679 from LifeSpan Bioscience

Prices	$475.00
Sizes	100 µl
Host	Rabbit
Clonality	Monoclonal
Clone	EP550Y

IHC of paraffin-embedded human breast carcinoma using anti-MEKK2 antibody.

Anti-MAP3K2 / MEKK2 Antibody (N-Terminus, clone EP626Y) - LS-C49631 from LifeSpan Bioscience

Prices	$505.00
Sizes	100 µl
Host	Rabbit
Clonality	Monoclonal
Clone	EP626Y

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