NEIL3

Gene Symbol NEIL3
Entrez Gene 55247
Alt Symbol FGP2, FPG2, NEI3, ZGRF3, hFPG2, hNEI3
Species Human
Gene Type protein-coding
Description nei endonuclease VIII-like 3 (E. coli)
Other Description DNA glycosylase FPG2|DNA glycosylase hFPG2|DNA glycosylase/AP lyase Neil3|endonuclease 8-like 3|endonuclease VIII-like 3|nei-like protein 3|zinc finger, GRF-type containing 3
Swissprots Q9NV95 Q8NG51 Q2PPJ3 Q8TAT5
Accessions ABC40719 CDH92855 EAX04716 Q8TAT5 AB079071 BAC06479 AI419161 AK001720 BAA91860 AK307692 BC025954 AAH25954 BE865481 BP380910 CN426741 NM_018248 NP_060718
Function DNA glycosylase which prefers single-stranded DNA (ssDNA), or partially ssDNA structures such as bubble and fork structures, to double-stranded DNA (dsDNA). In vitro, displays strong glycosylase activity towards the hydantoin lesions spiroiminodihydantoin (Sp) and guanidinohydantoin (Gh) in both ssDNA and dsDNA; also recognizes FapyA, FapyG, 5-OHU, 5-OHC, 5- OHMH, Tg and 8-oxoA lesions in ssDNA. No activity on 8-oxoG detected. Also shows weak DNA-(apurinic or apyrimidinic site) lyase activity. In vivo, appears to be the primary enzyme involved in removing Sp and Gh from ssDNA in neonatal tissues. Seems to be an important facilitator of cell proliferation in certain populations, for example neural stem/progenitor cells and tumor cells, suggesting a role in replication-associated DNA repair. {ECO:0000269|PubMed:12433996, ECO:0000269|PubMed:19170771, ECO:0000269|PubMed:22569481, ECO:0000269|PubMed:23755964}.
Subcellular Location Nucleus {ECO:0000269|PubMed:12433996}.
Tissue Specificity Expressed in keratinocytes and embryonic fibroblasts (at protein level). Also detected in thymus, testis and fetal lung primary fibroblasts. {ECO:0000269|PubMed:12433996, ECO:0000269|PubMed:16428305, ECO:0000269|PubMed:19426544, ECO:0000269|PubMed:22365498}.
Top Pathways Base excision repair

NEIL3 (D-15) - sc-50745 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
NEIL3 (D-15): sc-50745. Western blot analysis of human recombinant NEIL3 fusion protein.

NEIL3 (H-194) - sc-134834 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
NEIL3 (H-194): sc-134834. Western blot analysis of NEIL3 expression in human testis tissue extract (A) and Hs 181 Tes whole cell lysate (B).

NEIL3 (S-20) - sc-50749 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

NEIL3 (M-194) - sc-134835 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
NEIL3 (M-194): sc-134835. Western blot analysis of NEIL3 expression in non-transfected: sc-117752 (A) and mouse NEIL3 transfected: sc-121995 (B) 293T whole cell lysates.

NEIL3 (2627C1b) - sc-81331 from Santa Cruz Biotechnology

Prices $295.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
NEIL3 (2627C1b): sc-81331 Western Blot analysis of human recombinant NEIL3 fusion protein.

Anti-NEI3 antibody - ab110049 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-NEI3 antibody (ab110049) at 1/500 dilutionLane 1 : COLO cell extractLane 2 : HuvEc cell extractLane 3 : HepG2 cell extractLane 4 : HeLa cell extractLane 5 : HuvEc cell extract with immunising peptide at 10 µgLysates/proteins at 30 µg per lane.

Anti-NEI3 antibody - ab174205 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-NEI3 antibody (ab174205) at 1/100 dilution + HL-60 cell line lysate at 35 µg

Anti-NEI3 antibody - ab94352 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-NEI3 antibody [2627C1b] - ab58643 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2627C1b
Anti-NEI3 antibody [2627C1b] (ab58643) + immunized recombinant protein

Anti-NEI3 / NEIL3 Antibody - LS-C73216 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal

Anti-NEI3 / NEIL3 Antibody - LS-C83002 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-NEI3 / NEIL3 Antibody (aa292-320, APC) - LS-C207324 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-NEI3 / NEIL3 Antibody (clone 2627C1b) - LS-C184557 from LifeSpan Bioscience

Prices $335.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 2627C1b

Anti-NEI3 / NEIL3 Antibody (aa292-320, AP) - LS-C207325 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-NEI3 / NEIL3 Antibody (aa292-320, Biotin) - LS-C207326 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-NEI3 / NEIL3 Antibody (aa292-320, FITC) - LS-C207327 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-NEI3 / NEIL3 Antibody (aa292-320, Azide-free, HRP) - LS-C207328 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-NEI3 / NEIL3 Antibody (aa292-320, PE) - LS-C208974 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-NEI3 / NEIL3 Antibody (aa291-320) - LS-C323286 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-NEI3 / NEIL3 Antibody (aa491-540) - LS-C119958 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of extracts from HeLa/HepG2/HUVEC/COLO cells, using NEIL3 Antibody. The lane on the right is treated with the synthesized peptide.

Anti-NEI3 / NEIL3 Antibody (aa292-320) - LS-C157994 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
NEIL3 Antibody western blot of HL-60 cell line lysates (35 ug/lane). The NEIL3 antibody detected the NEIL3 protein (arrow).

Anti-NEI3 / NEIL3 Antibody (clone 2627C1b) - LS-C342594 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2627C1b
Western blot analysis of immunized recombinant protein, using anti-NEIL3 monoclonal antibody.

Anti-NEI3 / NEIL3 Antibody (aa164-177) IHC-plus™ - LS-B4815 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-NEIL3 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B4815 concentration 10 ug/ml.

Anti-NEI3 / NEIL3 Antibody (aa164-177) IHC-plus™ - LS-B259 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-NEIL3 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B259 concentration 5 ug/ml.

NEI3 Antibody - NB100-441 from Novus Biologicals

Prices $229.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
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