NEIL3

Gene Symbol NEIL3
Entrez Gene 55247
Alt Symbol FGP2, FPG2, NEI3, ZGRF3, hFPG2, hNEI3
Species Human
Gene Type protein-coding
Description nei endonuclease VIII-like 3 (E. coli)
Other Description DNA glycosylase FPG2|DNA glycosylase hFPG2|DNA glycosylase/AP lyase Neil3|endonuclease 8-like 3|endonuclease VIII-like 3|nei-like protein 3|zinc finger, GRF-type containing 3
Swissprots Q9NV95 Q8NG51 Q2PPJ3 Q8TAT5
Accessions ABC40719 CDH92855 EAX04716 Q8TAT5 AB079071 BAC06479 AI419161 AK001720 BAA91860 AK307692 BC025954 AAH25954 BE865481 BP380910 CN426741 NM_018248 NP_060718
Function DNA glycosylase which prefers single-stranded DNA (ssDNA), or partially ssDNA structures such as bubble and fork structures, to double-stranded DNA (dsDNA). In vitro, displays strong glycosylase activity towards the hydantoin lesions spiroiminodihydantoin (Sp) and guanidinohydantoin (Gh) in both ssDNA and dsDNA; also recognizes FapyA, FapyG, 5-OHU, 5-OHC, 5- OHMH, Tg and 8-oxoA lesions in ssDNA. No activity on 8-oxoG detected. Also shows weak DNA-(apurinic or apyrimidinic site) lyase activity. In vivo, appears to be the primary enzyme involved in removing Sp and Gh from ssDNA in neonatal tissues. Seems to be an important facilitator of cell proliferation in certain populations, for example neural stem/progenitor cells and tumor cells, suggesting a role in replication-associated DNA repair. {ECO:0000269|PubMed:12433996, ECO:0000269|PubMed:19170771, ECO:0000269|PubMed:22569481, ECO:0000269|PubMed:23755964}.
Subcellular Location Nucleus {ECO:0000269|PubMed:12433996}.
Tissue Specificity Expressed in keratinocytes and embryonic fibroblasts (at protein level). Also detected in thymus, testis and fetal lung primary fibroblasts. {ECO:0000269|PubMed:12433996, ECO:0000269|PubMed:16428305, ECO:0000269|PubMed:19426544, ECO:0000269|PubMed:22365498}.
Top Pathways Base excision repair

Mouse NEI3 / NEIL3 ELISA Kit (Sandwich ELISA) - LS-F9410 from LifeSpan Bioscience

Category ELISA Kit
Prices $810.00
Sizes 1 plate
Sensitivity 0.061 ng/ml
Range 0.156-10 ng/ml

Mouse NEI3 / NEIL3 ELISA Kit (Sandwich ELISA) - LS-F12134 from LifeSpan Bioscience

Category ELISA Kit
Prices $600.00
Sizes 1 plate
Sensitivity 0.78
Range 0.156-10 ng/ml

Endonuclease 8-like 3, NEIL3, Human, ELISA Kit - E4282h from ARP American Research Products

Category ELISA Kit
Prices $660.00
Sizes 96 t

nei endonuclease VIII-like 3 (E. coli) , ELISA Kit - MBS9341634 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

ELISA Kit for Nei Endonuclease VIII Like Protein 3 (NEIL3) - SEN291Mu from Uscn Life Science Inc.

Category ELISA Kit
Sensitivity The minimum detectable dose of this kit is typically less than 0.061ng/mL.
Range 0.156-10ng/mL The standard curve concentrations used for the ELISA’s were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

Human NEI3 / NEIL3 ELISA Kit (Custom ELISA) - LS-F19926 from LifeSpan Bioscience

Category ELISA Kit
Prices $600.00
Sizes 1 plate
Sensitivity To be determined
Range 0.156-10 ng/ml

Bovine NEI3 / NEIL3 ELISA Kit (Custom ELISA) - LS-F19927 from LifeSpan Bioscience

Category ELISA Kit
Prices $700.00
Sizes 1 plate
Sensitivity To be determined
Range 0.156-10 ng/ml

Human NEIL3 ELISA Kit - E013034 from Biobool

Category ELISA Kit

NEIL3 ELISA Kit (Human) (OKEH05107) - OKEH05107 from Aviva Systems Biology

Category ELISA Kit
Prices $470.00
Sizes 96 wells
Sensitivity 0.39 ng/mL
Range 0.78-50 ng/mL

Endonuclease 8-like 3, ELISA Kit - MBS2884973 from MyBioSource

Category ELISA Kit
Prices $430.00, $570.00, $2,515.00, $4,520.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Endonuclease 8-like 3, ELISA Kit - MBS760985 from MyBioSource

Category ELISA Kit
Prices $295.00, $390.00, $1,615.00, $3,015.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity 0.469ng/ml
Range 0.78-50ng/ml

Mouse NEI3 / NEIL3 ELISA Kit (Sandwich ELISA) - LS-F33883 from LifeSpan Bioscience

Category ELISA Kit
Sensitivity 0.469
Range 0.156-10 ng/ml

Rat NEI3 / NEIL3 ELISA Kit (Competitive EIA) - LS-F38877 from LifeSpan Bioscience

Category ELISA Kit
Sensitivity 49.3
Range 0.156-10 ng/ml
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