NEIL3

Gene Symbol	NEIL3
Entrez Gene	55247
Alt Symbol	FGP2, FPG2, NEI3, ZGRF3, hFPG2, hNEI3
Species	Human
Gene Type	protein-coding
Description	nei endonuclease VIII-like 3 (E. coli)
Other Description	DNA glycosylase FPG2|DNA glycosylase hFPG2|DNA glycosylase/AP lyase Neil3|endonuclease 8-like 3|endonuclease VIII-like 3|nei-like protein 3|zinc finger, GRF-type containing 3
Swissprots	Q9NV95 Q8NG51 Q2PPJ3 Q8TAT5
Accessions	ABC40719 CDH92855 EAX04716 Q8TAT5 AB079071 BAC06479 AI419161 AK001720 BAA91860 AK307692 BC025954 AAH25954 BE865481 BP380910 CN426741 NM_018248 NP_060718
Function	DNA glycosylase which prefers single-stranded DNA (ssDNA), or partially ssDNA structures such as bubble and fork structures, to double-stranded DNA (dsDNA). In vitro, displays strong glycosylase activity towards the hydantoin lesions spiroiminodihydantoin (Sp) and guanidinohydantoin (Gh) in both ssDNA and dsDNA; also recognizes FapyA, FapyG, 5-OHU, 5-OHC, 5- OHMH, Tg and 8-oxoA lesions in ssDNA. No activity on 8-oxoG detected. Also shows weak DNA-(apurinic or apyrimidinic site) lyase activity. In vivo, appears to be the primary enzyme involved in removing Sp and Gh from ssDNA in neonatal tissues. Seems to be an important facilitator of cell proliferation in certain populations, for example neural stem/progenitor cells and tumor cells, suggesting a role in replication-associated DNA repair. {ECO:0000269|PubMed:12433996, ECO:0000269|PubMed:19170771, ECO:0000269|PubMed:22569481, ECO:0000269|PubMed:23755964}.
Subcellular Location	Nucleus {ECO:0000269|PubMed:12433996}.
Tissue Specificity	Expressed in keratinocytes and embryonic fibroblasts (at protein level). Also detected in thymus, testis and fetal lung primary fibroblasts. {ECO:0000269|PubMed:12433996, ECO:0000269|PubMed:16428305, ECO:0000269|PubMed:19426544, ECO:0000269|PubMed:22365498}.
Top Pathways	Base excision repair

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• Cell/Tissue/Blood Products

NEIL3 overexpression lysate - LY413189 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

NEIL3 293 Cell Lysate - 406384 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg Species Escherichia coli

NEI3 Overexpression Lysate (Native) - NBL1-13581 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

NEIL3 Over-expression Lysate Product - GWB-F90B65 from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

Panoply™ Human NEIL3 Knockdown Stable Cell Line - CSC-DC010285 from Creative biogene Category Cell Line Species Human

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