NEIL3

Gene Symbol NEIL3
Entrez Gene 55247
Alt Symbol FGP2, FPG2, NEI3, ZGRF3, hFPG2, hNEI3
Species Human
Gene Type protein-coding
Description nei endonuclease VIII-like 3 (E. coli)
Other Description DNA glycosylase FPG2|DNA glycosylase hFPG2|DNA glycosylase/AP lyase Neil3|endonuclease 8-like 3|endonuclease VIII-like 3|nei-like protein 3|zinc finger, GRF-type containing 3
Swissprots Q9NV95 Q8NG51 Q2PPJ3 Q8TAT5
Accessions ABC40719 CDH92855 EAX04716 Q8TAT5 AB079071 BAC06479 AI419161 AK001720 BAA91860 AK307692 BC025954 AAH25954 BE865481 BP380910 CN426741 NM_018248 NP_060718
Function DNA glycosylase which prefers single-stranded DNA (ssDNA), or partially ssDNA structures such as bubble and fork structures, to double-stranded DNA (dsDNA). In vitro, displays strong glycosylase activity towards the hydantoin lesions spiroiminodihydantoin (Sp) and guanidinohydantoin (Gh) in both ssDNA and dsDNA; also recognizes FapyA, FapyG, 5-OHU, 5-OHC, 5- OHMH, Tg and 8-oxoA lesions in ssDNA. No activity on 8-oxoG detected. Also shows weak DNA-(apurinic or apyrimidinic site) lyase activity. In vivo, appears to be the primary enzyme involved in removing Sp and Gh from ssDNA in neonatal tissues. Seems to be an important facilitator of cell proliferation in certain populations, for example neural stem/progenitor cells and tumor cells, suggesting a role in replication-associated DNA repair. {ECO:0000269|PubMed:12433996, ECO:0000269|PubMed:19170771, ECO:0000269|PubMed:22569481, ECO:0000269|PubMed:23755964}.
Subcellular Location Nucleus {ECO:0000269|PubMed:12433996}.
Tissue Specificity Expressed in keratinocytes and embryonic fibroblasts (at protein level). Also detected in thymus, testis and fetal lung primary fibroblasts. {ECO:0000269|PubMed:12433996, ECO:0000269|PubMed:16428305, ECO:0000269|PubMed:19426544, ECO:0000269|PubMed:22365498}.
Top Pathways Base excision repair

NEI3 / NEIL3 Antibody Blocking Peptide - LS-E6609 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

NEIL3-AntibodyCenter-Blocking-peptide - BP19397c from Abgent, a WuXi AppTec company

Category Peptide
Prices $80.00
Sizes 100 µg

NEIL3 Blocking Peptide - abx063899 from Abbexa

Category Peptide
Species Human, Mouse, Rat

NEIL3 fusion protein - ag2200 from Proteintech Group

Category Protein
Source E. coli-derived, PGEX-4T
Species Human

NEIL3 fusion protein - ag18624 from Proteintech Group

Category Protein
Source E. coli-derived, PET28a
Species Human

Recombinant Human NEIL3 - NEIL3-912H from Creative Biomart

Category Protein
Source Mammalian Cells
Species Human

Recombinant Nei Endonuclease VIII Like Protein 3 (NEIL3) - RPN291Mu01 from Uscn Life Science Inc.

Category Protein
Source E.coli
Species Mouse

Recombinant Nei Endonuclease VIII Like Protein 3 (NEIL3) - RPN291Mu02 from Uscn Life Science Inc.

Category Protein
Source E.coli
Species Mouse

NEIL3 Blocking Peptide - CBP2705 from Cohesion Biosciences

Category Peptide
Prices $100.00, $300.00
Sizes 1 mg, 5 mg
Species Human, Mouse, Rat

Recombinant Human Endonuclease 8-like 3(NEIL3) - CSB-YP855036HU CSB-EP855036HU CSB-BP855036HU CSB-MP855036HU from Cusabio

Category Protein
Source Yeast or E.coli or Baculovirus or Mammalian cell
Species Human

NEIL3 Protein - abx164869 from Abbexa

Category Protein
Species Human, Mouse

NEIL3 Peptide, Human - M34GP10285H from Creative Peptides

Category Peptide
Source Synthetic.
Species Human

NEI3 Recombinant Protein Antigen - NBP2-56282PEP from Novus Biologicals

Category Protein
Prices $199.00
Sizes 100 µl
Source E.coli
Species Human

Endonuclease 8-like 3 (NEIL3), Recombinant Protein - MBS1313224 from MyBioSource

Category Protein
Prices $1,405.00, $1,405.00, $1,635.00, $1,635.00, $2,330.00, $2,330.00, $2,770.00, $2,770.00, $2,770.00, $4,610.00
Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 50 µg (Mammalian-Cell), 500 µg (Yeast), 1 mg (E-Coli), 100 µg (Baculovirus), 100 µg (Mammalian-Cell), 1 mg (Yeast), 500 µg (Baculovirus), 50 µl (Concentrate)
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Human
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