Gene Symbol | CCL4 |
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Entrez Gene | 6351 |
Alt Symbol | ACT2, AT744.1, G-26, HC21, LAG-1, LAG1, MIP-1-beta, MIP1B, MIP1B1, SCYA2, SCYA4 |
Species | Human |
Gene Type | protein-coding |
Description | chemokine (C-C motif) ligand 4 |
Other Description | C-C motif chemokine 4|G-26 T-lymphocyte-secreted protein|MIP-1-beta(1-69)|PAT 744|SIS-gamma|T-cell activation protein 2|lymphocyte activation gene 1 protein|macrophage inflammatory protein 1-beta|secreted protein G-26|small inducible cytokine A4 (homologous to mouse Mip-1b) |
Swissprots | Q3SXL8 Q13704 P13236 Q6FGI8 P22617 |
Accessions | AAX07292 AAX07293 EAW80098 P13236 AA362169 AY312578 AAR16183 AY766446 AAX07305 AY766448 AAX07307 BC027961 BC104226 AAI04227 BC104227 AAI04228 BC107433 AAI07434 CR542119 CAG46916 J04130 AAA51576 M23502 AAA36656 M25316 AAA57256 M57503 AAA36752 X16166 CAA34291 X53683 CAA37723 NM_002984 NP_002975 |
Function | Monokine with inflammatory and chemokinetic properties. Binds to CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-beta induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form MIP-1-beta(3-69) retains the abilities to induce down-modulation of surface expression of the chemokine receptor CCR5 and to inhibit the CCR5- mediated entry of HIV-1 in T-cells. MIP-1-beta(3-69) is also a ligand for CCR1 and CCR2 isoform B. {ECO:0000269|PubMed:10540332, ECO:0000269|PubMed:12070155, ECO:0000269|PubMed:8525373}. |
Subcellular Location | Secreted. |
Top Pathways | Cytokine-cytokine receptor interaction, Toll-like receptor signaling pathway, Cytosolic DNA-sensing pathway, Chemokine signaling pathway, Salmonella infection |
Rat CCL4 / MIP-1 Beta ELISA Kit (Sandwich ELISA) - LS-F2774 from LifeSpan Bioscience
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Rat CCL4 / MIP-1 Beta ELISA Kit (Sandwich ELISA) - LS-F5525 from LifeSpan Bioscience
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Human CCL4 / MIP-1 Beta ELISA Kit (Sandwich ELISA) - LS-F2505 from LifeSpan Bioscience
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Human CCL4 / MIP-1 Beta ELISA Kit (Sandwich ELISA) - LS-F4953 from LifeSpan Bioscience
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Mouse CCL4 / MIP-1 Beta ELISA Kit (Sandwich ELISA) - LS-F4954 from LifeSpan Bioscience
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Chicken CCL4 / MIP-1 Beta ELISA Kit (Sandwich ELISA) - LS-F6158 from LifeSpan Bioscience
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Rabbit CCL4 / MIP-1 Beta ELISA Kit (Sandwich ELISA) - LS-F6159 from LifeSpan Bioscience
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Mouse CCL4 / MIP-1 Beta ELISA Kit (Sandwich ELISA) - LS-F976 from LifeSpan Bioscience
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Human CCL4 / MIP-1 Beta ELISA Kit (Sandwich ELISA) - LS-F11062 from LifeSpan Bioscience
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Mouse CCL4 / MIP-1 Beta ELISA Kit (Sandwich ELISA) - LS-F11063 from LifeSpan Bioscience
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Human MIP-1 β / CCL4 ELISA Kit - RAB0075 from Sigma-Aldrich
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CCL4/MIP-1 beta BioAssay ELISA Kit, Human - 143753 from USBiological Life Science
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CCL4/MIP-1 beta BioAssay ELISA Kit, Rat - 143754 from USBiological Life Science
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Human CCL4/MIP-1 beta Biotin Fluorokine Flow Cytometry Kit - NFBM0 from R&D Systems
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Human CCL4/MIP-1 beta Luminex Performance Assay - LUH271 from R&D Systems |
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Human CCL4/MIP-1 beta Magnetic Luminex Performance Assay - LUHM271 from R&D Systems |
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Human CCL4/MIP-1 beta Quantikine ELISA Kit - DMB00 from R&D Systems
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Human CCL4/MIP-1 beta Quantikine PharmPak (50 Plates) - PDMB00 from R&D Systems
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Human CCL4/MIP-1 beta Quantikine SixPak (6 Plates) - SMB00 from R&D Systems
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Human CCL4/MIP-1 beta DuoSet ELISA - DY271 from R&D Systems
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Mouse CCL4/MIP-1 beta Quantikine ELISA Kit - MMB00 from R&D Systems
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Mouse CCL4/MIP-1 beta DuoSet ELISA - DY451 from R&D Systems
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Canine CCL4/MIP-1 beta DuoSet ELISA - DY5839 from R&D Systems
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Human CCL4/MIP-1 beta DuoSet, 5 Plate - DY271-05 from R&D Systems
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Human CCL4 ELISA Kit - abx056047 from Abbexa
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