CCL4

Gene Symbol CCL4
Entrez Gene 6351
Alt Symbol ACT2, AT744.1, G-26, HC21, LAG-1, LAG1, MIP-1-beta, MIP1B, MIP1B1, SCYA2, SCYA4
Species Human
Gene Type protein-coding
Description chemokine (C-C motif) ligand 4
Other Description C-C motif chemokine 4|G-26 T-lymphocyte-secreted protein|MIP-1-beta(1-69)|PAT 744|SIS-gamma|T-cell activation protein 2|lymphocyte activation gene 1 protein|macrophage inflammatory protein 1-beta|secreted protein G-26|small inducible cytokine A4 (homologous to mouse Mip-1b)
Swissprots Q3SXL8 Q13704 P13236 Q6FGI8 P22617
Accessions AAX07292 AAX07293 EAW80098 P13236 AA362169 AY312578 AAR16183 AY766446 AAX07305 AY766448 AAX07307 BC027961 BC104226 AAI04227 BC104227 AAI04228 BC107433 AAI07434 CR542119 CAG46916 J04130 AAA51576 M23502 AAA36656 M25316 AAA57256 M57503 AAA36752 X16166 CAA34291 X53683 CAA37723 NM_002984 NP_002975
Function Monokine with inflammatory and chemokinetic properties. Binds to CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-beta induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form MIP-1-beta(3-69) retains the abilities to induce down-modulation of surface expression of the chemokine receptor CCR5 and to inhibit the CCR5- mediated entry of HIV-1 in T-cells. MIP-1-beta(3-69) is also a ligand for CCR1 and CCR2 isoform B. {ECO:0000269|PubMed:10540332, ECO:0000269|PubMed:12070155, ECO:0000269|PubMed:8525373}.
Subcellular Location Secreted.
Top Pathways Cytokine-cytokine receptor interaction, Toll-like receptor signaling pathway, Cytosolic DNA-sensing pathway, Chemokine signaling pathway, Salmonella infection

MIP-1β (C-15) - sc-1385 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Western blot analysis of mouse recombinant MIP-1β (A) and human recombinant MIP-1β at 25 ng (B) and 50 ng (C). Antibodies tested include MIP-1β (M-20): sc-1387 (A) and MIP-1β (C-15): sc-1385 (B,C).

MIP-1β (M-42) - sc-367243 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

MIP-1β (3H3) - sc-130330 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
MIP-1β (3H3): sc-130330. Western blot analysis of human recombinant MIP-1β.

Anti-CCL4 / MIP-1 Beta Antibody - LS-C8611 from LifeSpan Bioscience

Prices $605.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-CCL4 / MIP-1 Beta Antibody - LS-C8614 from LifeSpan Bioscience

Prices $515.00
Sizes 500 µg
Host Mouse
Clonality Monoclonal

Anti-CCL4 / MIP-1 Beta Antibody - LS-C8612 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-CCL4 / MIP-1 Beta Antibody (aa1-69) - LS-C25342 from LifeSpan Bioscience

Prices $425.00
Sizes 250 µg
Host Rabbit
Clonality Polyclonal

Anti-CCL4 / MIP-1 Beta Antibody (aa1-69) - LS-C48848 from LifeSpan Bioscience

Prices $445.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-CCL4 / SYCA4 Antibody - LS-C71940 from LifeSpan Bioscience

Prices $530.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-CCL4 / SYCA4 Antibody (aa27-92) - LS-C71941 from LifeSpan Bioscience

Prices $650.00
Sizes 50 µg
Host Chicken
Clonality Polyclonal

Anti-CCL4 / MIP-1 Beta Antibody (Biotin) - LS-C86673 from LifeSpan Bioscience

Prices $405.00
Sizes 25 µg
Host Rabbit
Clonality Polyclonal

Anti-CCL4 / MIP-1 Beta Antibody - LS-C86945 from LifeSpan Bioscience

Prices $345.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-CCL4 / SYCA4 Antibody (C-Terminus, clone EP494Y) - LS-C49702 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EP494Y
Western blot of anti-MIP1 beta (C-term) antibody, dilution 1:500000 (approximately 0.05 ug/lane [0.5 ug/200ul] of recombinant protein was loaded on the membrane).

Anti-CCL4 / MIP-1 Beta Antibody (Biotin) - LS-C104473 from LifeSpan Bioscience

Prices $285.00, $325.00
Sizes 25 µg, 50 µg
Host Rabbit
Clonality Polyclonal

Anti-CCL4 / MIP-1 Beta Antibody (Biotin) - LS-C104795 from LifeSpan Bioscience

Prices $285.00, $325.00
Sizes 25 µg, 50 µg
Host Rabbit
Clonality Polyclonal

Anti-CCL4 / MIP-1 Beta Antibody (HRP) - LS-C154109 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-CCL4 / MIP-1 Beta Antibody (clone 3H3) - LS-C137617 from LifeSpan Bioscience

Prices $415.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 3H3

Anti-CCL4 / MIP-1 Beta Antibody (Biotin) - LS-C154124 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-CCL4 / MIP-1 Beta Antibody (aa74-88) - LS-C172288 from LifeSpan Bioscience

Prices $295.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-CCL4 / MIP-1 Beta Antibody (aa74-88, Magnetic beads) - LS-C172289 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-CCL4 / MIP-1 Beta Antibody (aa74-88, Sepharose) - LS-C172290 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-CCL4 / SYCA4 Antibody (N-Terminus, clone EP521Y) - LS-C49703 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EP521Y
Western blot of anti-MIP1 beta (N-term) antibody, dilution 1:500000 (approximately 0.05 ug/lane [0.5 ug/200ul] of recombinant protein was loaded on the membrane).

Anti-CCL4 / MIP-1 Beta Antibody - LS-C194987 from LifeSpan Bioscience

Prices $650.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-CCL4 / MIP-1 Beta Antibody - LS-C153848 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of protein-A purified Anti-MIP-1 (CCL4) antibody shows detection of recombinant swine MIP-1 (CCL4) raised in yeast. The protein was purified and resolved by SDS-PAGE, then transferred to PVDF membrane. Membrane was blocked with 3% BSA (BSA-30, diluted 1:10), and probed with 4 g/mL primary antibody overnight at 4C. After washing, membrane was probed with IRDye800 Conjugated Goat Anti-Rabbit IgG (p/n 611-132-122) at 1:20000 for 45 min at room temperature.

Anti-CCL4 / MIP-1 Beta Antibody (aa29-56, FITC) - LS-C253749 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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