CCL4

Gene Symbol CCL4
Entrez Gene 6351
Alt Symbol ACT2, AT744.1, G-26, HC21, LAG-1, LAG1, MIP-1-beta, MIP1B, MIP1B1, SCYA2, SCYA4
Species Human
Gene Type protein-coding
Description chemokine (C-C motif) ligand 4
Other Description C-C motif chemokine 4|G-26 T-lymphocyte-secreted protein|MIP-1-beta(1-69)|PAT 744|SIS-gamma|T-cell activation protein 2|lymphocyte activation gene 1 protein|macrophage inflammatory protein 1-beta|secreted protein G-26|small inducible cytokine A4 (homologous to mouse Mip-1b)
Swissprots Q3SXL8 Q13704 P13236 Q6FGI8 P22617
Accessions AAX07292 AAX07293 EAW80098 P13236 AA362169 AY312578 AAR16183 AY766446 AAX07305 AY766448 AAX07307 BC027961 BC104226 AAI04227 BC104227 AAI04228 BC107433 AAI07434 CR542119 CAG46916 J04130 AAA51576 M23502 AAA36656 M25316 AAA57256 M57503 AAA36752 X16166 CAA34291 X53683 CAA37723 NM_002984 NP_002975
Function Monokine with inflammatory and chemokinetic properties. Binds to CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-beta induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form MIP-1-beta(3-69) retains the abilities to induce down-modulation of surface expression of the chemokine receptor CCR5 and to inhibit the CCR5- mediated entry of HIV-1 in T-cells. MIP-1-beta(3-69) is also a ligand for CCR1 and CCR2 isoform B. {ECO:0000269|PubMed:10540332, ECO:0000269|PubMed:12070155, ECO:0000269|PubMed:8525373}.
Subcellular Location Secreted.
Top Pathways Cytokine-cytokine receptor interaction, Toll-like receptor signaling pathway, Cytosolic DNA-sensing pathway, Chemokine signaling pathway, Salmonella infection

MIP-1b CRISPR/Cas9 KO Plasmid (h) - sc-404782 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

MIP-1b HDR Plasmid (h) - sc-404782-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MIP-1b Double Nickase Plasmid (h) - sc-404782-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MIP-1b Double Nickase Plasmid (h2) - sc-404782-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MIP-1b CRISPR Activation Plasmid (h) - sc-404782-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

MIP-1b CRISPR Activation Plasmid (h2) - sc-404782-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

MIP-1b Lentiviral Activation Particles (h) - sc-404782-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MIP-1b Lentiviral Activation Particles (h2) - sc-404782-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MIP-1β siRNA (h) - sc-43932 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MIP-1β shRNA Plasmid (h) - sc-43932-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MIP-1β shRNA (h) Lentiviral Particles - sc-43932-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CCL4/MIP-1 beta RNAi - H00006351-R02 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU116731 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN5618 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND5618 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR02404 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr02404

CCL4 siRNA (Human) - CRH4285 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

CCL4 - MBS8227571 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human CCL4 (NM_002984.2) - SHH257677 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human CCL4(NM_002984.2) - SHG151327 from Creative biogene

Category siRNA
Species Reactivities Human

CCL4 shRNA Plasmid (Human) - CHH4285 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

CCL4 miRNA 3'UTR clone - MiUTR1H-01806 from Creative biogene

Species Reactivities Human
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