| Gene Symbol |
CCL4
|
| Entrez Gene |
6351
|
| Alt Symbol |
ACT2, AT744.1, G-26, HC21, LAG-1, LAG1, MIP-1-beta, MIP1B, MIP1B1, SCYA2, SCYA4
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
chemokine (C-C motif) ligand 4
|
| Other Description |
C-C motif chemokine 4|G-26 T-lymphocyte-secreted protein|MIP-1-beta(1-69)|PAT 744|SIS-gamma|T-cell activation protein 2|lymphocyte activation gene 1 protein|macrophage inflammatory protein 1-beta|secreted protein G-26|small inducible cytokine A4 (homologous to mouse Mip-1b)
|
| Swissprots |
Q3SXL8 Q13704 P13236 Q6FGI8 P22617
|
| Accessions |
AAX07292 AAX07293 EAW80098 P13236 AA362169 AY312578 AAR16183 AY766446 AAX07305 AY766448 AAX07307 BC027961 BC104226 AAI04227 BC104227 AAI04228 BC107433 AAI07434 CR542119 CAG46916 J04130 AAA51576 M23502 AAA36656 M25316 AAA57256 M57503 AAA36752 X16166 CAA34291 X53683 CAA37723 NM_002984 NP_002975
|
| Function |
Monokine with inflammatory and chemokinetic properties. Binds to CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-beta induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form MIP-1-beta(3-69) retains the abilities to induce down-modulation of surface expression of the chemokine receptor CCR5 and to inhibit the CCR5- mediated entry of HIV-1 in T-cells. MIP-1-beta(3-69) is also a ligand for CCR1 and CCR2 isoform B. {ECO:0000269|PubMed:10540332, ECO:0000269|PubMed:12070155, ECO:0000269|PubMed:8525373}.
|
| Subcellular Location |
Secreted.
|
| Top Pathways |
Cytokine-cytokine receptor interaction, Toll-like receptor signaling pathway, Cytosolic DNA-sensing pathway, Chemokine signaling pathway, Salmonella infection
|
![Western Blot: Macrophage Inflammatory Protein 1 beta Overexpression Lysate (Adult Normal) [NBL1-08858] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Macrophage Inflammatory Protein 1 beta.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/11048_Macrophage%2520Inflammatory%2520Protein%25201%2520beta%2520Overexpression%2520Lysate%2520%2528Adult%2520Normal%2529-Western%2520Blot-NBL1-08858-img0002.jpg)