GCSAM

Gene Symbol GCSAM
Entrez Gene 257144
Alt Symbol GCAT2, GCET2, HGAL
Species Human
Gene Type protein-coding
Description germinal center-associated, signaling and motility
Other Description germinal center B-cell-expressed transcript 2 protein|germinal center expressed transcript 2|germinal center-associated lymphoma protein|germinal center-associated signaling and motility protein|human germinal center-associated lymphoma
Swissprots C9JD17 Q8N6F7 C9JUG6
Accessions EAW79680 Q8N6F7 AA237025 AF521911 AAO21701 AK313368 BAG36167 AW576133 AY212246 AAO22147 BC030506 AAH30506 BM456595 BP224611 BX280641 DA455714 HQ447219 ADQ31706 XM_005247272 XP_005247329 XM_011512627 XP_011510929 XM_011512628 XP_011510930 XM_011512629 XP_011510931 XM_011512630 XP_011510932 NM_001190259 NP_001177188 NM_001190260 NP_001177189 NM_152785 NP_689998 NM_001008756
Function Involved in the negative regulation of lymphocyte motility. It mediates the migration-inhibitory effects of IL6. Serves as a positive regulator of the RhoA signaling pathway. Enhancement of RhoA activation results in inhibition of lymphocyte and lymphoma cell motility by activation of its downstream effector ROCK. Is a regulator of B-cell receptor signaling, that acts through SYK kinase activation. {ECO:0000269|PubMed:17823310, ECO:0000269|PubMed:20844236, ECO:0000269|PubMed:23299888}.
Subcellular Location Cytoplasm. Cell membrane. Note=It relocalizes from the cytoplasm to podosome-like structures upon cell treatment with IL6.
Tissue Specificity Expressed in diffuse large B-cell lymphoma (DLBCL) and several germinal center (GC)-like lymphoma cell lines (at protein level). Highly expressed in normal GC lymphocytes and GC-derived malignancies. Expressed in thymus and spleen. {ECO:0000269|PubMed:12509382, ECO:0000269|PubMed:12819018, ECO:0000269|PubMed:15677569}.

GCET2-Over-expression-Lysate - LY14017a from Abgent, a WuXi AppTec company

Category Cell Lysate
Prices $325.00
Sizes 100 µg
Western blot analysis of his-tag GCET2 (arrow) using his tag antibody. 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the GCET2 gene.

GCET2 293T Cell Transient Overexpression Lysate(Denatured) - H00257144-T01 from Acris Antibodies

Category Cell Lysate
Prices $320.00
Sizes 100 µl

GCSAM overexpression lysate - LY433768 from Acris Antibodies

Category Cell Lysate
Prices $280.00
Sizes 100 µg

GCET2 Overexpression Lysate (Denatured) - H00257144-T01 from Novus Biologicals

Category Cell Lysate
Prices $279.00
Sizes 100 µl
GCET2 transfected lysate.

GCET2 Overexpression Lysate (Native) - NBL1-11004 from Novus Biologicals

Category Cell Lysate
Prices $329.00
Sizes 100 µg
Western Blot: GCET2 Overexpression Lysate (Adult Normal) [NBL1-11004] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for GCET2.

GCET2 Over-expression Lysate Product - GWB-F4AFFB from Genway Biotech

Category Cell Lysate
Prices $445.00
Sizes 100 µg
Species Human

Panoply™ Human GCSAM Knockdown Stable Cell Line - CSC-DC006176 from Creative biogene

Category Cell Line
Species Human
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