GCSAM

Gene Symbol	GCSAM
Entrez Gene	257144
Alt Symbol	GCAT2, GCET2, HGAL
Species	Human
Gene Type	protein-coding
Description	germinal center-associated, signaling and motility
Other Description	germinal center B-cell-expressed transcript 2 protein|germinal center expressed transcript 2|germinal center-associated lymphoma protein|germinal center-associated signaling and motility protein|human germinal center-associated lymphoma
Swissprots	C9JD17 Q8N6F7 C9JUG6
Accessions	EAW79680 Q8N6F7 AA237025 AF521911 AAO21701 AK313368 BAG36167 AW576133 AY212246 AAO22147 BC030506 AAH30506 BM456595 BP224611 BX280641 DA455714 HQ447219 ADQ31706 XM_005247272 XP_005247329 XM_011512627 XP_011510929 XM_011512628 XP_011510930 XM_011512629 XP_011510931 XM_011512630 XP_011510932 NM_001190259 NP_001177188 NM_001190260 NP_001177189 NM_152785 NP_689998 NM_001008756
Function	Involved in the negative regulation of lymphocyte motility. It mediates the migration-inhibitory effects of IL6. Serves as a positive regulator of the RhoA signaling pathway. Enhancement of RhoA activation results in inhibition of lymphocyte and lymphoma cell motility by activation of its downstream effector ROCK. Is a regulator of B-cell receptor signaling, that acts through SYK kinase activation. {ECO:0000269|PubMed:17823310, ECO:0000269|PubMed:20844236, ECO:0000269|PubMed:23299888}.
Subcellular Location	Cytoplasm. Cell membrane. Note=It relocalizes from the cytoplasm to podosome-like structures upon cell treatment with IL6.
Tissue Specificity	Expressed in diffuse large B-cell lymphoma (DLBCL) and several germinal center (GC)-like lymphoma cell lines (at protein level). Highly expressed in normal GC lymphocytes and GC-derived malignancies. Expressed in thymus and spleen. {ECO:0000269|PubMed:12509382, ECO:0000269|PubMed:12819018, ECO:0000269|PubMed:15677569}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human GCET2 full length protein - ab137147 from Abcam Category Protein Source E. coli Species Human

GCET2 / HGAL Antibody Blocking Peptide - LS-E20085 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

GCET2 Partial Recombinant Protein - H00257144-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

GCET2 Recombinant Protein - H00257144-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human GCET2 Protein - NBP2-23075 from Novus Biologicals Category Protein Prices $269.00 Sizes 100 µg Source E.coli Species Human

Human GCSAM protein - orb168384 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 20 μg Species Human

GCET2 Blocking Peptide - 33R-10243 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

GCET2 protein (His tag) - 80R-2585 from Fitzgerald Category Protein Prices $270.00 Sizes 100 µg Source E.coli

GCET2 / GAL (1-178, His-tag) - AR50631PU-N from Acris Antibodies Category Protein Prices $790.00 Sizes 500 µg Source E. coli Species Human

GCET2 / GAL (1-178, His-tag) - AR50631PU-S from Acris Antibodies Category Protein Prices $340.00 Sizes 100 µg Source E. coli Species Human

GCET2 / GAL - H00257144-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

GCET2 / GAL - H00257144-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

GCET2 / GAL - H00257144-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

GCET2 / GAL - H00257144-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

GCET2, 1-178 aa, Human, His tag, E.coli - 01-P1807 from ARP American Research Products Category Protein Prices $179.00, $369.00, $849.00 Sizes 20 µg, 100 µg, 500 µg Species Human

GCET2 fusion protein - ag14864 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

GCET2 fusion protein - ag4280 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

GCSAM Human - PRPS-1289 from NeoScientific Category Protein Prices $65.00, $169.00, $3,510.00 Sizes 5 µg, 20 µg, 1 mg Source E.coli. Species Human

Recombinant Human germinal center-associated, signaling and motility, His-tagged - GCET2-368H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human Germinal center B-cell-expressed transcript 2 protein(GCET2) - CSB-YP854052HU CSB-EP854052HU CSB-BP854052HU CSB-MP854052HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

GCET2, 1-178aa, Human, His tag, E.coli - ATGP1807 from ATGen Category Protein Prices $80.00, $240.00, $720.00 Sizes 20 µg, 100 µg, 500 µg Species Human

Germinal Center-Associated, Signaling and Motility Protein (Recombinant) - abx260976 from Abbexa Category Protein

GCET2 Recombinant Protein Antigen - NBP1-82693PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

GCSAM Peptide, Human - M34GP06176H from Creative Peptides Category Peptide Source Synthetic. Species Human

GCET2, Recombinant Protein - MBS204823 from MyBioSource Category Protein Prices $310.00, $720.00 Sizes 100 µg, 500 µg Source E Coli Species Human

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