| Gene Symbol |
GCSAM
|
| Entrez Gene |
257144
|
| Alt Symbol |
GCAT2, GCET2, HGAL
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
germinal center-associated, signaling and motility
|
| Other Description |
germinal center B-cell-expressed transcript 2 protein|germinal center expressed transcript 2|germinal center-associated lymphoma protein|germinal center-associated signaling and motility protein|human germinal center-associated lymphoma
|
| Swissprots |
C9JD17 Q8N6F7 C9JUG6
|
| Accessions |
EAW79680 Q8N6F7 AA237025 AF521911 AAO21701 AK313368 BAG36167 AW576133 AY212246 AAO22147 BC030506 AAH30506 BM456595 BP224611 BX280641 DA455714 HQ447219 ADQ31706 XM_005247272 XP_005247329 XM_011512627 XP_011510929 XM_011512628 XP_011510930 XM_011512629 XP_011510931 XM_011512630 XP_011510932 NM_001190259 NP_001177188 NM_001190260 NP_001177189 NM_152785 NP_689998 NM_001008756
|
| Function |
Involved in the negative regulation of lymphocyte motility. It mediates the migration-inhibitory effects of IL6. Serves as a positive regulator of the RhoA signaling pathway. Enhancement of RhoA activation results in inhibition of lymphocyte and lymphoma cell motility by activation of its downstream effector ROCK. Is a regulator of B-cell receptor signaling, that acts through SYK kinase activation. {ECO:0000269|PubMed:17823310, ECO:0000269|PubMed:20844236, ECO:0000269|PubMed:23299888}.
|
| Subcellular Location |
Cytoplasm. Cell membrane. Note=It relocalizes from the cytoplasm to podosome-like structures upon cell treatment with IL6.
|
| Tissue Specificity |
Expressed in diffuse large B-cell lymphoma (DLBCL) and several germinal center (GC)-like lymphoma cell lines (at protein level). Highly expressed in normal GC lymphocytes and GC-derived malignancies. Expressed in thymus and spleen. {ECO:0000269|PubMed:12509382, ECO:0000269|PubMed:12819018, ECO:0000269|PubMed:15677569}.
|