GCSAM
| Gene Symbol | GCSAM |
|---|---|
| Entrez Gene | 257144 |
| Alt Symbol | GCAT2, GCET2, HGAL |
| Species | Human |
| Gene Type | protein-coding |
| Description | germinal center-associated, signaling and motility |
| Other Description | germinal center B-cell-expressed transcript 2 protein|germinal center expressed transcript 2|germinal center-associated lymphoma protein|germinal center-associated signaling and motility protein|human germinal center-associated lymphoma |
| Swissprots | C9JD17 Q8N6F7 C9JUG6 |
| Accessions | EAW79680 Q8N6F7 AA237025 AF521911 AAO21701 AK313368 BAG36167 AW576133 AY212246 AAO22147 BC030506 AAH30506 BM456595 BP224611 BX280641 DA455714 HQ447219 ADQ31706 XM_005247272 XP_005247329 XM_011512627 XP_011510929 XM_011512628 XP_011510930 XM_011512629 XP_011510931 XM_011512630 XP_011510932 NM_001190259 NP_001177188 NM_001190260 NP_001177189 NM_152785 NP_689998 NM_001008756 |
| Function | Involved in the negative regulation of lymphocyte motility. It mediates the migration-inhibitory effects of IL6. Serves as a positive regulator of the RhoA signaling pathway. Enhancement of RhoA activation results in inhibition of lymphocyte and lymphoma cell motility by activation of its downstream effector ROCK. Is a regulator of B-cell receptor signaling, that acts through SYK kinase activation. {ECO:0000269|PubMed:17823310, ECO:0000269|PubMed:20844236, ECO:0000269|PubMed:23299888}. |
| Subcellular Location | Cytoplasm. Cell membrane. Note=It relocalizes from the cytoplasm to podosome-like structures upon cell treatment with IL6. |
| Tissue Specificity | Expressed in diffuse large B-cell lymphoma (DLBCL) and several germinal center (GC)-like lymphoma cell lines (at protein level). Highly expressed in normal GC lymphocytes and GC-derived malignancies. Expressed in thymus and spleen. {ECO:0000269|PubMed:12509382, ECO:0000269|PubMed:12819018, ECO:0000269|PubMed:15677569}. |
GCET2 CRISPR/Cas9 KO Plasmid (h) - sc-418185 from Santa Cruz Biotechnology
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GCET2 HDR Plasmid (h) - sc-418185-HDR from Santa Cruz Biotechnology
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GCET2 Double Nickase Plasmid (h) - sc-418185-NIC from Santa Cruz Biotechnology
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GCET2 Double Nickase Plasmid (h2) - sc-418185-NIC-2 from Santa Cruz Biotechnology
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GCET2 CRISPR Activation Plasmid (h) - sc-418185-ACT from Santa Cruz Biotechnology
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GCET2 CRISPR Activation Plasmid (h2) - sc-418185-ACT-2 from Santa Cruz Biotechnology
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GCET2 Lentiviral Activation Particles (h) - sc-418185-LAC from Santa Cruz Biotechnology
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GCET2 Lentiviral Activation Particles (h2) - sc-418185-LAC-2 from Santa Cruz Biotechnology
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GCET2 siRNA (h) - sc-78432 from Santa Cruz Biotechnology
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GCET2 shRNA Plasmid (h) - sc-78432-SH from Santa Cruz Biotechnology
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GCET2 shRNA (h) Lentiviral Particles - sc-78432-V from Santa Cruz Biotechnology
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GCET2 RNAi - H00257144-R01 from Novus Biologicals
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GCET2 RNAi - H00257144-R02 from Novus Biologicals
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MISSION® esiRNA - EHU025481 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN9183 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9183 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR11685 from Sigma-Aldrich
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GCSAM siRNA (Human) - CRJ6781 from Cohesion Biosciences
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GCSAM - MBS8221341 from MyBioSource
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shRNA set against Human GCET2 (NM_152785.4) - SHH299958 from Creative biogene
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Human GCSAM siRNA - orb277282 from Biorbyt
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GCSAM shRNA Plasmid (Human) - CHJ6781 from Cohesion Biosciences
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