HTRA1

Gene Symbol	HTRA1
Entrez Gene	5654
Alt Symbol	ARMD7, CARASIL, HtrA, L56, ORF480, PRSS11
Species	Human
Gene Type	protein-coding
Description	HtrA serine peptidase 1
Other Description	IGFBP5-protease|high-temperature requirement A serine peptidase 1|protease, serine, 11 (IGF binding)|serine protease HTRA1
Swissprots	Q9UNS5 Q92743 D3DRE4
Accessions	AAD41525 EAW49312 EAW49313 Q92743 AF070555 AF097709 AAC97211 AI423369 AK091944 BAG52446 AK092476 BAG52557 AK290089 BAF82778 BC011352 AAH11352 BC031082 BC156552 AAI56553 BC172536 AAI72536 BM993893 D87258 BAA13322 DA633502 Y07921 CAA69226 NM_002775 NP_002766
Function	Serine protease with a variety of targets, including extracellular matrix proteins such as fibronectin. HTRA1-generated fibronectin fragments further induce synovial cells to up-regulate MMP1 and MMP3 production. May also degrade proteoglycans, such as aggrecan, decorin and fibromodulin. Through cleavage of proteoglycans, may release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the extracellular space. Regulates the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. Inhibits signaling mediated by TGF-beta family members. This activity requires the integrity of the catalytic site, although it is unclear whether TGF-beta proteins are themselves degraded. By acting on TGF-beta signaling, may regulate many physiological processes, including retinal angiogenesis and neuronal survival and maturation during development. Intracellularly, degrades TSC2, leading to the activation of TSC2 downstream targets. {ECO:
Subcellular Location	Secreted. Cytoplasm, cytosol. Note=Predominantly secreted. Also found associated with the plasma membrane.
Tissue Specificity	Widely expressed, with strongest expression in placenta (at protein level). Secreted by synovial fibroblasts. Up- regulated in osteoarthritis and rheumatoid arthritis synovial fluids and cartilage as compared with non-arthritic (at protein level). {ECO:0000269|PubMed:15208355, ECO:0000269|PubMed:16377621, ECO:0000269|PubMed:9852107}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human HTRA1 ELISA Kit (Sandwich ELISA) - LS-F6692 from LifeSpan Bioscience Category ELISA Kit Prices $790.00 Sizes 1 plate Sensitivity 31.25 pg/ml Range 31.25-2000 pg/ml

Human HTRA1 ELISA Kit (Sandwich ELISA) - LS-F11673 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 78 pg/ml Range 31.25-2000 pg/ml

Human HTRA1 ELISA Kit - abx151881 from Abbexa Category ELISA Kit Sensitivity 14.3 pg/ml Range 31.25 pg/ml - 2000 pg/ml

HtrA Serine Peptidase 1 (HTRA1), Human, ELISA Kit - SEL604Hu from ARP American Research Products Category ELISA Kit Prices $790.00 Sizes 96 t Sensitivity 13.2pg/mL Range 31.2-2,000pg/mL

HtrA Serine Peptidase 1, HTRA1, Human, ELISA Kit - E-EL-H0423 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t Sensitivity 0.188 Range 0.313-20ng/mL

Serine protease HTRA1 (HTRA1), Human, ELISA Kit - CSB-EL010901HU from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

Serine protease HTRA1, HTRA1, Human, ELISA Kit - E2002h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t Range 78-5000 pg/mL

HtrA Serine, Peptidase 1, HTRA1, Rabbit, ELISA Kit - E-EL-RB1481 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

HtrA Serine, Peptidase 1, HTRA1, Chicken, ELISA Kit - E-EL-Ch1013 from ARP American Research Products Category ELISA Kit Prices $504.00 Sizes 96 t

HtrA Serine, Peptidase 1, HTRA1, Porcine, ELISA Kit - E-EL-P1750 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

HtrA Serine, Peptidase 1, HTRA1, Sheep, ELISA Kit - E-EL-S0543 from ARP American Research Products Category ELISA Kit Prices $648.00 Sizes 96 t

HtrA Serine, Peptidase 1, HTRA1, Monkey, ELISA Kit - E-EL-MK2008 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

HtrA Serine Peptidase 1 (HTRA1), Human, CLIA Kit - SCL604Hu from ARP American Research Products Category CLIA Kit Prices $840.00 Sizes 96 t Sensitivity 3.2pg/mL Range 8.2-6,000pg/mL

HtrA Serine Peptidase 1, ELISA Kit - MBS066593 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

HtrA Serine Peptidase 1, ELISA Kit - MBS084852 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

HtrA Serine Peptidase 1, ELISA Kit - MBS097931 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 10 pg/ml Range 62.5 pg/ml - 2000 pg/ml

HtrA Serine Peptidase 1, ELISA Kit - MBS103070 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

HtrA Serine Peptidase 1, ELISA Kit - MBS069791 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

HtrA Serine Peptidase 1, ELISA Kit - MBS075936 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

HtrA serine peptidase 1, ELISA Kit - MBS902316 from MyBioSource Category ELISA Kit Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity Typically less than 0.39 ng/ml.

HtrA Serine Peptidase 1, ELISA Kit - MBS051668 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

HtrA Serine Peptidase 1 (HTRA1), ELISA Kit - MBS2022469 from MyBioSource Category ELISA Kit Prices $410.00, $610.00, $830.00, $3,420.00, $6,200.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 13.2pg/mL. Range 31.2-2,000pg/mL. The standard curve concentrations used for the ELISA's were 2,000pg/mL, 1,000pg/mL, 500pg/mL, 250pg/mL, 125pg/mL, 62.5pg/mL, 31.2pg/mL.

Human HTRA1(HtrA Serine Peptidase 1) ELISA Kit - E-EL-H0423 from Elabscience Category ELISA Kit Sensitivity 0.19 ng/mL Range 0.31—20 ng/mL

Human HTRA1 (HtrA Serine Peptidase 1) CLIA Kit - E-CL-H0343 from Elabscience Category CLIA Kit Sensitivity 46.88 pg/mL Range Average Recovery (%)

HTRA1, ELISA Kit - MBS2504576 from MyBioSource Category ELISA Kit Prices $410.00, $490.00, $2,040.00, $3,590.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.188ng/mL Range 0.313-20ng/mL

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