HTRA1

Gene Symbol HTRA1
Entrez Gene 5654
Alt Symbol ARMD7, CARASIL, HtrA, L56, ORF480, PRSS11
Species Human
Gene Type protein-coding
Description HtrA serine peptidase 1
Other Description IGFBP5-protease|high-temperature requirement A serine peptidase 1|protease, serine, 11 (IGF binding)|serine protease HTRA1
Swissprots Q9UNS5 Q92743 D3DRE4
Accessions AAD41525 EAW49312 EAW49313 Q92743 AF070555 AF097709 AAC97211 AI423369 AK091944 BAG52446 AK092476 BAG52557 AK290089 BAF82778 BC011352 AAH11352 BC031082 BC156552 AAI56553 BC172536 AAI72536 BM993893 D87258 BAA13322 DA633502 Y07921 CAA69226 NM_002775 NP_002766
Function Serine protease with a variety of targets, including extracellular matrix proteins such as fibronectin. HTRA1-generated fibronectin fragments further induce synovial cells to up-regulate MMP1 and MMP3 production. May also degrade proteoglycans, such as aggrecan, decorin and fibromodulin. Through cleavage of proteoglycans, may release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the extracellular space. Regulates the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. Inhibits signaling mediated by TGF-beta family members. This activity requires the integrity of the catalytic site, although it is unclear whether TGF-beta proteins are themselves degraded. By acting on TGF-beta signaling, may regulate many physiological processes, including retinal angiogenesis and neuronal survival and maturation during development. Intracellularly, degrades TSC2, leading to the activation of TSC2 downstream targets. {ECO:
Subcellular Location Secreted. Cytoplasm, cytosol. Note=Predominantly secreted. Also found associated with the plasma membrane.
Tissue Specificity Widely expressed, with strongest expression in placenta (at protein level). Secreted by synovial fibroblasts. Up- regulated in osteoarthritis and rheumatoid arthritis synovial fluids and cartilage as compared with non-arthritic (at protein level). {ECO:0000269|PubMed:15208355, ECO:0000269|PubMed:16377621, ECO:0000269|PubMed:9852107}.

HtrA (B-8) - sc-377050 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
HtrA (B-8): sc-377050. Western blot analysis of HtrA expression in non-transfected: sc-117752 (A) and human HtrA transfected: sc-372521 (B) 293T whole cell lysates.

HtrA (C-19) - sc-15465 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

HtrA (H-95) - sc-50335 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
HtrA (H-95): sc-50335. Immunoperoxidase staining of formalin fixed, paraffin-embedded human kidney tissue showing cytoplasmic staining of cells in tubules.

HtrA (Z-24) - sc-130780 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
HtrA (Z-24): sc-130780. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human breast carcinoma tissue showing cytoplasmic localization.

Anti-htrA antibody - ab65481 from Abcam

Prices $370.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-htrA antibody (ab65481) at 1/2000 dilution + Synechocystis sp. PCC 6803 membrane proteins at 3 µgSecondaryanti-rabbit at 1/30000 dilutiondeveloped using the ECL technique

Anti-htrA1 antibody - ab38611 from Abcam

Prices $400.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-htrA1 antibody (ab38611) + Mouse brain tissue lysate.

Anti-htrA1 antibody - ab38610 from Abcam

Prices $379.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-htrA1 antibody (ab38610) at 1/1000 dilution + Human placenta tissue lysate at 35 µg/mlSecondaryPeroxidase-conjugated goat anti-rabbit IgG (H+L) at 1/5000 dilution

Anti-htrA1 antibody - ab65904 from Abcam

Prices $378.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-htrA1 antibody (ab65904) at 1/1000 dilutionLane 1 : Molecular weight markersLane 2 : HEK-293 with TNF-alpha treatment in Complete MediumLane 3 : HFL-1 in Serum Free conditionLane 4 : HFL-1 treated with TPALane 5 : HFL-1 treated with IL 1-BetaLane 6 : HFL-1 treated with Beta-EstradiolLane 7 : HFL-1 treated with Progesterone

Anti-htrA1 antibody - ab65902 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-htrA1 antibody (ab65902) at 1/1000 dilutionLane 1 : Molecular weight markersLane 2 : HEK-293 with TNF alpha in Complete MediumLane 3 : HFL-1 in Serum FreeLane 4 : HFL-1 treated with TPALane 5 : HFL-1 treated with IL 1-BetaLane 6 : HFL-1 treated with Beta-estradiolLane 7 : HFL-1 treated with Progesterone

Anti-htrA1 antibody [EPR14605(2)] - ab199529 from Abcam

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR14605(2)
All lanes : Anti-htrA1 antibody [EPR14605(2)] (ab199529) at 1/5000 dilutionLane 1 : HepG2 (Human liver hepatocellular carcinoma) cell lysateLane 2 : MCF7 (Human breast adenocarcinoma cell line) cell lysateLysates/proteins at 10 µg per lane.SecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/1000 dilution

Anti-htrA1 antibody - Carboxyterminal end - ab65905 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-htrA1 antibody - Carboxyterminal end (ab65905) at 1/1000 dilutionLane 1 : Molecular weight markersLane 2 : HEK-293 treated with TNF alpha in Complete MediumLane 3 : HFL-1 in Complete Medium with Serum Free conditionLane 4 : HFL-1 in Complete Medium, treatment with TPALane 5 : HFL-1 in Complete Medium, treatment with IL 1-BetaLane 6 : HFL-1 in Complete Medium, tretment with Beta-EstradiolLane 7 : HFL-1 in Complete Medium, treatment with Progesterone

Anti-htrA1 antibody - Catalytic domain - ab65903 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-htrA1 antibody - Catalytic domain (ab65903)Lane 1 : SW 620 lysate in Serum FreeLane 2 : SW 620 lysate treated with TPALane 3 : SW 620 lysate treated with IL 1-alphaLane 4 : SW 620 lysate treated with IL 1-betaLane 5 : Molecular weight markers

Anti-HTRA1 Antibody (aa234-249) - LS-C190914 from LifeSpan Bioscience

Prices $415.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-HTRA1 Antibody (N-Terminus, AP) - LS-C278265 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-HTRA1 Antibody (N-Terminus, APC) - LS-C278266 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-HTRA1 Antibody (N-Terminus, Biotin) - LS-C278267 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-HTRA1 Antibody (N-Terminus, FITC) - LS-C278268 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-HTRA1 Antibody (N-Terminus, Azide-free, HRP) - LS-C278269 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-HTRA1 Antibody (aa122-171) - LS-C146185 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
HTRA1 antibody LS-C146185 Western blot of Fetal Kidney lysate. Antibody concentration 1 ug/ml.

Anti-HTRA1 Antibody (N-Terminus, PE) - LS-C278270 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-HTRA1 Antibody (C-Terminus, AP) - LS-C278272 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-HTRA1 Antibody (C-Terminus, APC) - LS-C278271 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-HTRA1 Antibody (C-Terminus, Biotin) - LS-C278273 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-HTRA1 Antibody (C-Terminus, FITC) - LS-C278274 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-HTRA1 Antibody (C-Terminus, PE) - LS-C278276 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
Search more