HTRA1

Gene Symbol	HTRA1
Entrez Gene	5654
Alt Symbol	ARMD7, CARASIL, HtrA, L56, ORF480, PRSS11
Species	Human
Gene Type	protein-coding
Description	HtrA serine peptidase 1
Other Description	IGFBP5-protease|high-temperature requirement A serine peptidase 1|protease, serine, 11 (IGF binding)|serine protease HTRA1
Swissprots	Q9UNS5 Q92743 D3DRE4
Accessions	AAD41525 EAW49312 EAW49313 Q92743 AF070555 AF097709 AAC97211 AI423369 AK091944 BAG52446 AK092476 BAG52557 AK290089 BAF82778 BC011352 AAH11352 BC031082 BC156552 AAI56553 BC172536 AAI72536 BM993893 D87258 BAA13322 DA633502 Y07921 CAA69226 NM_002775 NP_002766
Function	Serine protease with a variety of targets, including extracellular matrix proteins such as fibronectin. HTRA1-generated fibronectin fragments further induce synovial cells to up-regulate MMP1 and MMP3 production. May also degrade proteoglycans, such as aggrecan, decorin and fibromodulin. Through cleavage of proteoglycans, may release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the extracellular space. Regulates the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. Inhibits signaling mediated by TGF-beta family members. This activity requires the integrity of the catalytic site, although it is unclear whether TGF-beta proteins are themselves degraded. By acting on TGF-beta signaling, may regulate many physiological processes, including retinal angiogenesis and neuronal survival and maturation during development. Intracellularly, degrades TSC2, leading to the activation of TSC2 downstream targets. {ECO:
Subcellular Location	Secreted. Cytoplasm, cytosol. Note=Predominantly secreted. Also found associated with the plasma membrane.
Tissue Specificity	Widely expressed, with strongest expression in placenta (at protein level). Secreted by synovial fibroblasts. Up- regulated in osteoarthritis and rheumatoid arthritis synovial fluids and cartilage as compared with non-arthritic (at protein level). {ECO:0000269|PubMed:15208355, ECO:0000269|PubMed:16377621, ECO:0000269|PubMed:9852107}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human htrA1 full length protein - ab134441 from Abcam Category Protein Prices $528.00 Sizes 25 µl Source Insect cells Species Human

Active human htrA1 protein fragment - ab134447 from Abcam Category Protein Prices $665.00 Sizes 25 µl Source E. coli Species Human

htrA (mutated S234 A) full length protein - ab191462 from Abcam Category Protein Prices $344.00 Sizes 20 µg Source E. coli

Human htrA1 full length protein - ab191464 from Abcam Category Protein Source Baculovirus infected sf9 cells Species Human

Human htrA1 peptide - ab112516 from Abcam Category Peptide Species Human

HTRA1 Antibody Blocking Peptide - LS-E2355 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

HTRA1 Antibody Blocking Peptide - LS-E2354 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

HTRA1 Antibody Blocking Peptide - LS-E23177 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

HTRA1/PRSS11 Peptide - P0340 from Novus Biologicals Category Peptide Species Human

HTRA1/PRSS11 Peptide - P0341 from Novus Biologicals Category Peptide Species Human

HtrA1-Antibody-C-term-Blocking-Peptide - BP1331b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

HtrA1-Antibody-N-term-Blocking-Peptide - BP1331a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant Human HTRA1, CF - 2916-SE-020 from R&D Systems Category Protein Source E. coli-derived, Gly156-Pro480, with an N-terminal Met and C-terminal 6-His tag

Human HTRA1 Protein - abx067140 from Abbexa Category Protein Source E.coli Species Human

HtrA Serine Peptidase 1 (HTRA1), Human - 20-9471 from ARP American Research Products Category Protein Prices $619.00 Sizes 50 µg Source E.coli Species Human

Recombinant Human HtrA1, His-tagged - HtrA1-2890H from Creative Biomart Category Protein Source insect cells .

Recombinant Human HTRA1, His-tagged - HTRA1-47H from Creative Biomart Category Protein Source Sf9 insect cells using baculovirus Species Human

Recombinant Human HtrA Serine Peptidase 1, His-tagged - HTRA1-2015H from Creative Biomart Category Protein Source insect cells.

Recombinant Human HtrA1, Truncated, His-tagged - HtrA1-2889H from Creative Biomart Category Protein Source E.coli.

Recombinant Human HTRA1, His-tagged - HTRA1-2891H from Creative Biomart Category Protein Source E.coli

Recombinant HtrA Serine Peptidase 1 (HTRA1) - RPL604Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant HtrA Serine Peptidase 1 (HTRA1) - RPL604Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Human Serine protease HTRA1(HTRA1) - CSB-YP835695HU CSB-EP835695HU CSB-BP835695HU CSB-MP835695HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Recombinant Human HTRA1 Protein, CF - 2916-SE from R&D Systems Category Protein Prices $329.00, $33,000.00 Sizes 20 µg, 20 µg Source E. coli -derived Gly156-Pro480, with an N-terminal Met and C-terminal 6-His tag Species Human

HtrA Serine Peptidase 1 (HTRA1) - RPU141944 from Biomatik Category Protein Prices $302.50, $605.00, $907.50 Sizes 10 µg, 50 µg, 100 µg Source E.coli Species Human

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