HTRA1

Gene Symbol HTRA1
Entrez Gene 5654
Alt Symbol ARMD7, CARASIL, HtrA, L56, ORF480, PRSS11
Species Human
Gene Type protein-coding
Description HtrA serine peptidase 1
Other Description IGFBP5-protease|high-temperature requirement A serine peptidase 1|protease, serine, 11 (IGF binding)|serine protease HTRA1
Swissprots Q9UNS5 Q92743 D3DRE4
Accessions AAD41525 EAW49312 EAW49313 Q92743 AF070555 AF097709 AAC97211 AI423369 AK091944 BAG52446 AK092476 BAG52557 AK290089 BAF82778 BC011352 AAH11352 BC031082 BC156552 AAI56553 BC172536 AAI72536 BM993893 D87258 BAA13322 DA633502 Y07921 CAA69226 NM_002775 NP_002766
Function Serine protease with a variety of targets, including extracellular matrix proteins such as fibronectin. HTRA1-generated fibronectin fragments further induce synovial cells to up-regulate MMP1 and MMP3 production. May also degrade proteoglycans, such as aggrecan, decorin and fibromodulin. Through cleavage of proteoglycans, may release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the extracellular space. Regulates the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. Inhibits signaling mediated by TGF-beta family members. This activity requires the integrity of the catalytic site, although it is unclear whether TGF-beta proteins are themselves degraded. By acting on TGF-beta signaling, may regulate many physiological processes, including retinal angiogenesis and neuronal survival and maturation during development. Intracellularly, degrades TSC2, leading to the activation of TSC2 downstream targets. {ECO:
Subcellular Location Secreted. Cytoplasm, cytosol. Note=Predominantly secreted. Also found associated with the plasma membrane.
Tissue Specificity Widely expressed, with strongest expression in placenta (at protein level). Secreted by synovial fibroblasts. Up- regulated in osteoarthritis and rheumatoid arthritis synovial fluids and cartilage as compared with non-arthritic (at protein level). {ECO:0000269|PubMed:15208355, ECO:0000269|PubMed:16377621, ECO:0000269|PubMed:9852107}.

HtrA CRISPR/Cas9 KO Plasmid (h) - sc-403306 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

HtrA HDR Plasmid (h) - sc-403306-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

HtrA Double Nickase Plasmid (h) - sc-403306-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

HtrA Double Nickase Plasmid (h2) - sc-403306-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

HtrA CRISPR Activation Plasmid (h) - sc-403306-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

HtrA CRISPR Activation Plasmid (h2) - sc-403306-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

HtrA Lentiviral Activation Particles (h) - sc-403306-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

HtrA Lentiviral Activation Particles (h2) - sc-403306-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

HtrA siRNA (h) - sc-43854 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

HtrA shRNA Plasmid (h) - sc-43854-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

HtrA shRNA (h) Lentiviral Particles - sc-43854-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CompoZr® Knockout ZFN Kit - CKOZFN2120 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2120 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR04071 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr04071

HTRA1 siRNA (Human) - CRH3812 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

HTRA1 - MBS8203195 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human HTRA1 (NM_002775.4) - SHH316041 from Creative biogene

Category siRNA
Species Reactivities Human

Human HTRA1 siRNA - orb264314 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

HTRA1 shRNA Plasmid (Human) - CHH3812 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

HTRA1 miRNA 3'UTR clone - MiUTR3H-04760 from Creative biogene

Species Reactivities Human
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