| Gene Symbol |
HTRA1
|
| Entrez Gene |
5654
|
| Alt Symbol |
ARMD7, CARASIL, HtrA, L56, ORF480, PRSS11
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
HtrA serine peptidase 1
|
| Other Description |
IGFBP5-protease|high-temperature requirement A serine peptidase 1|protease, serine, 11 (IGF binding)|serine protease HTRA1
|
| Swissprots |
Q9UNS5 Q92743 D3DRE4
|
| Accessions |
AAD41525 EAW49312 EAW49313 Q92743 AF070555 AF097709 AAC97211 AI423369 AK091944 BAG52446 AK092476 BAG52557 AK290089 BAF82778 BC011352 AAH11352 BC031082 BC156552 AAI56553 BC172536 AAI72536 BM993893 D87258 BAA13322 DA633502 Y07921 CAA69226 NM_002775 NP_002766
|
| Function |
Serine protease with a variety of targets, including extracellular matrix proteins such as fibronectin. HTRA1-generated fibronectin fragments further induce synovial cells to up-regulate MMP1 and MMP3 production. May also degrade proteoglycans, such as aggrecan, decorin and fibromodulin. Through cleavage of proteoglycans, may release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the extracellular space. Regulates the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. Inhibits signaling mediated by TGF-beta family members. This activity requires the integrity of the catalytic site, although it is unclear whether TGF-beta proteins are themselves degraded. By acting on TGF-beta signaling, may regulate many physiological processes, including retinal angiogenesis and neuronal survival and maturation during development. Intracellularly, degrades TSC2, leading to the activation of TSC2 downstream targets. {ECO:
|
| Subcellular Location |
Secreted. Cytoplasm, cytosol. Note=Predominantly secreted. Also found associated with the plasma membrane.
|
| Tissue Specificity |
Widely expressed, with strongest expression in placenta (at protein level). Secreted by synovial fibroblasts. Up- regulated in osteoarthritis and rheumatoid arthritis synovial fluids and cartilage as compared with non-arthritic (at protein level). {ECO:0000269|PubMed:15208355, ECO:0000269|PubMed:16377621, ECO:0000269|PubMed:9852107}.
|