| Gene Symbol |
ASF1A
|
| Entrez Gene |
25842
|
| Alt Symbol |
CGI-98, CIA, HSPC146
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
anti-silencing function 1A histone chaperone
|
| Other Description |
ASF1 anti-silencing function 1 homolog A|CCG1-interacting factor A|anti-silencing function protein 1 homolog A|hAsf1|hAsf1a|hCIA|histone chaperone ASF1A
|
| Swissprots |
Q9P014 Q6IA08 Q9Y294
|
| Accessions |
EAW48193 Q9Y294 AA481056 AB028628 BAA96542 AF151856 AAD34093 AF161495 AAF29110 AF279306 AAK82972 AK025738 BAB15228 AL050261 CAB43363 BC010878 AAH10878 CR457347 CAG33628 DA902777 HQ447977 ADQ32460 NM_014034 NP_054753
|
| Function |
Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly and with HIRA to promote replication-independent chromatin assembly. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit. {ECO:0000269|PubMed:10759893, ECO:0000269|PubMed:11897662, ECO:0000269|PubMed:12842904, ECO:0000269|PubMed:14718166, ECO:0000269|PubMed:15621527, ECO:0000269|PubMed:15664198, ECO:0000269|PubMed:16151251}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:11897662, ECO:0000269|PubMed:12842904}.
|
| Tissue Specificity |
Ubiquitously expressed. {ECO:0000269|PubMed:12842904}.
|