Gene Symbol | ASF1A |
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Entrez Gene | 25842 |
Alt Symbol | CGI-98, CIA, HSPC146 |
Species | Human |
Gene Type | protein-coding |
Description | anti-silencing function 1A histone chaperone |
Other Description | ASF1 anti-silencing function 1 homolog A|CCG1-interacting factor A|anti-silencing function protein 1 homolog A|hAsf1|hAsf1a|hCIA|histone chaperone ASF1A |
Swissprots | Q9P014 Q6IA08 Q9Y294 |
Accessions | EAW48193 Q9Y294 AA481056 AB028628 BAA96542 AF151856 AAD34093 AF161495 AAF29110 AF279306 AAK82972 AK025738 BAB15228 AL050261 CAB43363 BC010878 AAH10878 CR457347 CAG33628 DA902777 HQ447977 ADQ32460 NM_014034 NP_054753 |
Function | Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly and with HIRA to promote replication-independent chromatin assembly. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit. {ECO:0000269|PubMed:10759893, ECO:0000269|PubMed:11897662, ECO:0000269|PubMed:12842904, ECO:0000269|PubMed:14718166, ECO:0000269|PubMed:15621527, ECO:0000269|PubMed:15664198, ECO:0000269|PubMed:16151251}. |
Subcellular Location | Nucleus {ECO:0000269|PubMed:11897662, ECO:0000269|PubMed:12842904}. |
Tissue Specificity | Ubiquitously expressed. {ECO:0000269|PubMed:12842904}. |
ASF1A CRISPR/Cas9 KO Plasmid (h) - sc-404071 from Santa Cruz Biotechnology
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ASF1A HDR Plasmid (h) - sc-404071-HDR from Santa Cruz Biotechnology
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ASF1A Double Nickase Plasmid (h) - sc-404071-NIC from Santa Cruz Biotechnology
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ASF1A Double Nickase Plasmid (h2) - sc-404071-NIC-2 from Santa Cruz Biotechnology
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ASF1A CRISPR Activation Plasmid (h) - sc-404071-ACT from Santa Cruz Biotechnology
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ASF1A CRISPR Activation Plasmid (h2) - sc-404071-ACT-2 from Santa Cruz Biotechnology
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ASF1A Lentiviral Activation Particles (h) - sc-404071-LAC from Santa Cruz Biotechnology
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ASF1A Lentiviral Activation Particles (h2) - sc-404071-LAC-2 from Santa Cruz Biotechnology
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ASF1A siRNA (h) - sc-95595 from Santa Cruz Biotechnology
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ASF1A shRNA Plasmid (h) - sc-95595-SH from Santa Cruz Biotechnology
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ASF1A shRNA (h) Lentiviral Particles - sc-95595-V from Santa Cruz Biotechnology
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ASF1a RNAi - H00025842-R01 from Novus Biologicals
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MISSION® esiRNA - EHU005561 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN3592 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3592 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR09809 from Sigma-Aldrich
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ASF1A siRNA (Human) - CRH8537 from Cohesion Biosciences
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ASF1A - MBS8225562 from MyBioSource
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shRNA set against Human ASF1A (NM_014034.2) - SHH241430 from Creative biogene
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shRNA set against Human ASF1A(NM_014034.2) - SHG077383 from Creative biogene
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Human ASF1A siRNA - orb269039 from Biorbyt
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ASF1A shRNA Plasmid (Human) - CHH8537 from Cohesion Biosciences
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ASF1A miRNA 3'UTR clone - MiUTR1H-00632 from Creative biogene
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