Gene Symbol | ASF1A |
---|---|
Entrez Gene | 25842 |
Alt Symbol | CGI-98, CIA, HSPC146 |
Species | Human |
Gene Type | protein-coding |
Description | anti-silencing function 1A histone chaperone |
Other Description | ASF1 anti-silencing function 1 homolog A|CCG1-interacting factor A|anti-silencing function protein 1 homolog A|hAsf1|hAsf1a|hCIA|histone chaperone ASF1A |
Swissprots | Q9P014 Q6IA08 Q9Y294 |
Accessions | EAW48193 Q9Y294 AA481056 AB028628 BAA96542 AF151856 AAD34093 AF161495 AAF29110 AF279306 AAK82972 AK025738 BAB15228 AL050261 CAB43363 BC010878 AAH10878 CR457347 CAG33628 DA902777 HQ447977 ADQ32460 NM_014034 NP_054753 |
Function | Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly and with HIRA to promote replication-independent chromatin assembly. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit. {ECO:0000269|PubMed:10759893, ECO:0000269|PubMed:11897662, ECO:0000269|PubMed:12842904, ECO:0000269|PubMed:14718166, ECO:0000269|PubMed:15621527, ECO:0000269|PubMed:15664198, ECO:0000269|PubMed:16151251}. |
Subcellular Location | Nucleus {ECO:0000269|PubMed:11897662, ECO:0000269|PubMed:12842904}. |
Tissue Specificity | Ubiquitously expressed. {ECO:0000269|PubMed:12842904}. |