HHLA2

Gene Symbol HHLA2
Entrez Gene 11148
Alt Symbol B7H7
Species Human
Gene Type protein-coding
Description HERV-H LTR-associating 2
Other Description HERV-H LTR-associating protein 2|human endogenous retrovirus-H long terminal repeat-associating protein 2
Swissprots Q9NWQ6 B4DKN2 Q9UM44 D3DN60
Accessions EAW79727 EAW79728 Q9UM44 AF126162 AAD48396 AK000692 BAA91323 AK027132 AK097806 AK296644 BAG59244 AK315109 BC035971 AAH35971 BM980981 BP293912 DQ892610 ABM83536 DQ895850 ABM86776 XM_005247080 XP_005247137 XM_011512362 XP_011510664 XM_011512363 XP_011510665 XM_011512364 XP_011510666 XM_011512365 XP_011510667 XM_011512366 XP_011510668 XM_011512367 XP_011510669 XR_924094 XR_924095 NM_001282556 NP_001269485 NM_001282557 NP_001269486 NM_001282558 NP_001269487 NM_001282559 NP_001269488 NM_007072 NP_009003
Function Through interaction with TMIGD2, costimulates T-cells in the context of TCR-mediated activation. Enhances T-cell proliferation and cytokine production via an AKT-dependent signaling cascade. {ECO:0000269|PubMed:23784006}.
Subcellular Location Membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Tissue Specificity Expressed at high levels in colon, kidney, testis, lung and pancreas, and at lower levels in small intestine, liver and skeletal muscle. In immune cells, highly expressed in B- cells, dendritic cells and macrophages. Not detected in T-cells. {ECO:0000269|PubMed:10444326, ECO:0000269|PubMed:23784006}.

HHLA2 (A-20) - sc-99927 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

HHLA2 (N-14) - sc-99929 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-HHLA2 antibody - ab107119 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-HHLA2 antibody (ab107119) at 1/100 dilution + MDA-MB231 cell line lysate at 35 µg

Anti-HHLA2 antibody - ab68548 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-HHLA2 antibody (ab68548) at 1/500 dilutionLane 1 : HHLA2 transfected 293T cell lysateLane 2 : Non-transfected 293T cell lysateLysates/proteins at 25 µg per lane.SecondaryGoat Anti-Mouse IgG (H&L) at 1/2500 dilution

Anti-HHLA2 antibody [EPR9313] - ab139694 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR9313
All lanes : Anti-HHLA2 antibody [EPR9313] (ab139694) at 1/1000 dilutionLane 1 : Human fetal lung lysateLane 2 : Caco 2 cell lysateLane 3 : 293T cell lysateLane 4 : MDA-MB-435 cell lysateLysates/proteins at 10 µg per lane.SecondaryStandard HRP labelled goat anti-rabbit at 1/2000 dilutiondeveloped using the ECL technique

Anti-HHLA2 Antibody (aa65-95, AP) - LS-C236210 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-HHLA2 Antibody (aa65-95, APC) - LS-C246741 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-HHLA2 Antibody (aa65-95, Biotin) - LS-C246742 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-HHLA2 Antibody (aa65-95, PE) - LS-C246744 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-HHLA2 Antibody (aa65-95, FITC) - LS-C246743 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-HHLA2 Antibody - LS-C308228 from LifeSpan Bioscience

Prices $455.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

Anti-HHLA2 Antibody (aa58-87) - LS-C321945 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-HHLA2 Antibody (aa65-95, Azide-free, HRP) - LS-C249186 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-HHLA2 Antibody (aa65-95) - LS-C166860 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
HHLA2 Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human colon carcinoma followed by peroxidase-conjugated secondary antibody and DAB staining.

B7-H7/HHLA2 Antibody - NBP1-86358 from Novus Biologicals

Host Rabbit
Clonality Polyclonal
Immunocytochemistry/Immunofluorescence: B7-H7/HHLA2 Antibody [NBP1-86358] - HHLA2 Antibody [NBP1-86358] - Immunofluorescent staining of human cell line U-2 OS shows positivity in cytoplasm.

B7-H7/HHLA2 Antibody - H00011148-B01P from Novus Biologicals

Prices $359.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

HHLA2 Polyclonal Antibody - bs-8419R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin embedded human rectal carcinoma tissue labeled with Anti HHLA2 Polyclonal Antibody, Unconjugated (bs-8419R) at 1:200 followed by conjugation to the secondary antibody and DAB staining

Anti-HHLA2 antibody produced in rabbit - HPA029417 from Sigma-Aldrich

Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-HHLA2: <B>Cat. No. HPA029417</B>: Immunohistochemical staining of human hippocampus shows moderate cytoplasmic positivity in neuronal cells.

Anti-HHLA2 antibody produced in mouse - SAB1407109 from Sigma-Aldrich

Prices $347.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-HHLA2: <B>Cat. No. SAB1407109</B>: Antibody concentration: 0.1-5 μg/mL. Specific band of ~45.5 kDa using HHLA2 transfected 293T lysate.<BR/><B>Lanes</B><BR/>1. Transfected 293T lysate.<BR/>2. Non-transfected 293T lysate.

HHLA2 Antibody - N-terminal region (OAAB00667) - OAAB00667 from Aviva Systems Biology

Prices $289.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal

HHLA2-Antibody-N-term - AP10650a from Abgent, a WuXi AppTec company

Prices $99.00, $295.00
Sizes 80 µl, 400 µl
Host Rabbit
Clonality Polyclonal
HHLA2 Antibody (N-term) (Cat. #AP10650a) immunohistochemistry analysis in formalin fixed and paraffin embedded human colon carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the HHLA2 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.

HHLA2 antibody - GTX51981 from GeneTex

Prices $319.00
Sizes 100 μl
Host Rabbit
Clonality Polyclonal
Anti-HHLA2 antibody used in IHC (Formalin-fixed paraffin-embedded sections). GTX51981

Human B7-H7/HHLA2 Antibody - MAB8084 from R&D Systems

Prices $99.00, $259.00
Sizes 25 µg, 100 µg
Host Mouse
Clone 907816
B7-H7/HHLA2 in Human PBMCs. B7-H7/HHLA2 was detected in immersion fixed human peripheral blood mononuclear cells (PBMCs) using Mouse Anti-Human B7-H7/HHLA2 Monoclonal Antibody (Catalog # MAB8084) at 25 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 557-conjugated Anti-Mouse IgG Secondary Antibody (yellow; Catalog # NL007 ) and counterstained with DAPI (blue). Specific staining was localized to cytoplasm. View our protocol for Fluorescent ICC Staining of Non-adherent Cells .

Human B7-H7 MAb (Clone 907816), Mouse IgG1 - MAB8084-SP from R&D Systems

Host Mouse
Clonality Monoclonal
Clone 907816
B7-H7 in Human PBMCs. B7-H7 was detected in immersion fixed human peripheral blood mononuclear cells (PBMCs) using Mouse Anti-Human B7-H7 Monoclonal Antibody (Catalog # MAB8084) at 25 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 557-conjugated Anti-Mouse IgG Secondary Antibody (yellow; Catalog # NL007) and counterstained with DAPI (blue). Specific staining was localized to cytoplasm. View our protocol for Fluorescent ICC Staining of Non-adherent Cells.
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