| Gene Symbol |
HHLA2
|
| Entrez Gene |
11148
|
| Alt Symbol |
B7H7
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
HERV-H LTR-associating 2
|
| Other Description |
HERV-H LTR-associating protein 2|human endogenous retrovirus-H long terminal repeat-associating protein 2
|
| Swissprots |
Q9NWQ6 B4DKN2 Q9UM44 D3DN60
|
| Accessions |
EAW79727 EAW79728 Q9UM44 AF126162 AAD48396 AK000692 BAA91323 AK027132 AK097806 AK296644 BAG59244 AK315109 BC035971 AAH35971 BM980981 BP293912 DQ892610 ABM83536 DQ895850 ABM86776 XM_005247080 XP_005247137 XM_011512362 XP_011510664 XM_011512363 XP_011510665 XM_011512364 XP_011510666 XM_011512365 XP_011510667 XM_011512366 XP_011510668 XM_011512367 XP_011510669 XR_924094 XR_924095 NM_001282556 NP_001269485 NM_001282557 NP_001269486 NM_001282558 NP_001269487 NM_001282559 NP_001269488 NM_007072 NP_009003
|
| Function |
Through interaction with TMIGD2, costimulates T-cells in the context of TCR-mediated activation. Enhances T-cell proliferation and cytokine production via an AKT-dependent signaling cascade. {ECO:0000269|PubMed:23784006}.
|
| Subcellular Location |
Membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
|
| Tissue Specificity |
Expressed at high levels in colon, kidney, testis, lung and pancreas, and at lower levels in small intestine, liver and skeletal muscle. In immune cells, highly expressed in B- cells, dendritic cells and macrophages. Not detected in T-cells. {ECO:0000269|PubMed:10444326, ECO:0000269|PubMed:23784006}.
|
![Western Blot: HHLA2 Overexpression Lysate (Adult Normal) [NBL1-11534] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for HHLA2.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/8521_HHLA2%2520Overexpression%2520Lysate%2520%2528Adult%2520Normal%2529-Western%2520Blot-NBL1-11534-img0002.jpg)