| Gene Symbol |
BPI
|
| Entrez Gene |
671
|
| Alt Symbol |
BPIFD1, rBPI
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
bactericidal/permeability-increasing protein
|
| Other Description |
BPI fold containing family D, member 1|CAP 57|bactericidal permeability-increasing protein|recombinant BPI holoprotein, rBPI
|
| Swissprots |
B2RCY2 Q9UD65 P17213 Q9H1L2 Q5JRW0 Q9UCT4 Q9H203 Q9BYZ9 Q1ZZU8 Q9H1M8 Q8IW58
|
| Accessions |
CAG28072 EAW76035 P17213 AF322588 AAG42844 AI436120 AK296568 BAG59188 AK315328 BAG37729 AX713278 CAD88641 AX746123 CAD97475 AX752831 CAD99178 BC032230 BC040955 AAH40955 BP306215 DQ414688 ABD66755 J04739 AAA51841 XM_005260522 XP_005260579 XM_011529012 XP_011527314 XR_430313 NM_001725 NP_001716
|
| Function |
The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. Has antibacterial activity against the Gram-nagative bacterium P.aeruginosa, this activity is inhibited by LPS from P.aeruginosa. {ECO:0000269|PubMed:1937776, ECO:0000269|PubMed:2722846}.
|
| Subcellular Location |
Secreted. Cytoplasmic granule membrane. Note=Membrane-associated in polymorphonuclear Leukocytes (PMN) granules.
|
| Tissue Specificity |
Restricted to cells of the myeloid series.
|
![Western Blot: BPI Overexpression Lysate (Adult Normal) [NBL1-08020] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for BPI.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/8432_BPI%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-08020-img0002.jpg)