DIO3

Gene Symbol DIO3
Entrez Gene 1735
Alt Symbol 5DIII, D3, DIOIII, TXDI3
Species Human
Gene Type protein-coding
Description deiodinase, iodothyronine, type III
Other Description iodothyronine deiodinase, placental type|thyroxine deiodinase type III (selenoprotein)|type 3 DI|type 3 iodothyronine selenodeiodinase|type III iodothyronine deiodinase|type-III 5' deiodinase|type-III 5'-deiodinase
Swissprots P55073 Q8WVN5 G3XAM0
Accessions EAW81747 P55073 AK292310 BAF84999 BC017717 AAH17717 BX161470 CAD61926 S79854 AAB35616 NM_001362 NP_001353
Function Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine) into RT3 (3,3',5'-triiodothyronine) and of T3 (3,5,3'-triiodothyronine) into T2 (3,3'-diiodothyronine). RT3 and T2 are inactive metabolites. May play a role in preventing premature exposure of developing fetal tissues to adult levels of thyroid hormones. Can regulate circulating fetal thyroid hormone concentrations throughout gestation. Essential role for regulation of thyroid hormone inactivation during embryological development. {ECO:0000269|PubMed:7593630}.
Subcellular Location Cell membrane {ECO:0000269|PubMed:12419801}; Single-pass type II membrane protein {ECO:0000269|PubMed:12419801}. Endosome membrane {ECO:0000269|PubMed:12419801}; Single-pass type II membrane protein {ECO:0000269|PubMed:12419801}.
Tissue Specificity Expressed in placenta and several fetal tissues.

DIO3 (A-19) - sc-69388 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-Dio3 antibody - ab102926 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-Dio3 antibody (ab102926) at 1/100 dilution + HepG2 cell line lysate at 35 µg

Anti-Dio3 antibody - ab135860 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-Dio3 antibody (ab135860) at 1/500 dilution + HUVEC cell extracts at 30 µg

Anti-Dio3 antibody - ab82041 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-Dio3 antibody (ab82041) at 0.5 µg/ml + rat placenta lysate

Anti-DIO3 Antibody (aa250-278, AP) - LS-C256117 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DIO3 Antibody (aa250-278, APC) - LS-C256118 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DIO3 Antibody (aa250-278, FITC) - LS-C256119 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DIO3 Antibody (aa250-278, PE) - LS-C256120 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DIO3 Antibody (aa17-66) - LS-C199830 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of DIO3 antibody in extracts from HUVEC cells.

Anti-DIO3 Antibody (Glu66) - LS-C177532 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of DIO3 (E66) pAb in extracts from HUVEC cells.

Anti-DIO3 Antibody (aa249-278) - LS-C320845 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DIO3 Antibody (aa250-278) - LS-C167418 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin-embedded human hepatocarcinoma reacted with DIO3 Antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

DIO3 Antibody - NBP1-05767 from Novus Biologicals

Prices $99.00, $299.00
Sizes 25 µl, 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: DIO3 Antibody [NBP1-05767] - Detection of Dio3 in rat placenta.

DIO3 Antibody - NB110-96414 from Novus Biologicals

Prices $99.00, $299.00
Sizes 25 µl, 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: DIO3 Antibody [NB110-96414] - Detection of Dio3 in rat placenta

DIO3 Antibody [Biotin] - NBP1-05767B from Novus Biologicals

Prices $299.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Flow Cytometry: DIO3 Antibody [Biotin] [NBP1-05767B] - Dio3 staining on mouse hepatic stellate cell cultured for 7 days. Image from verified customer review.

DIO3 Antibody [FITC] - NB110-96414F from Novus Biologicals

Prices $299.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

DIO3 Antibody [DyLight 405] - NB110-96414V from Novus Biologicals

Prices $319.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

DIO3 Antibody [Alexa Fluor (R) 647] - NB110-96414AF647 from Novus Biologicals

Prices $319.00
Sizes 100 tests
Host Rabbit
Clonality Polyclonal

DIO3 Antibody [Alexa Fluor (R) 488] - NB110-96414AF488 from Novus Biologicals

Prices $329.00
Sizes 100 tests
Host Rabbit
Clonality Polyclonal

DIO3 Antibody [Alexa Fluor (R) 405] - NB110-96414AF405 from Novus Biologicals

Prices $319.00
Sizes 100 tests
Host Rabbit
Clonality Polyclonal

DIO3 Antibody [Alexa Fluor (R) 700] - NB110-96414AF700 from Novus Biologicals

Prices $319.00
Sizes 100 tests
Host Rabbit
Clonality Polyclonal

DIO3 Antibody [DyLight 488] - NBP1-05767G from Novus Biologicals

Prices $319.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

DIO3 Antibody [DyLight 550] - NBP1-05767R from Novus Biologicals

Prices $319.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

DIO3 Antibody [DyLight 550] - NB110-96414R from Novus Biologicals

Prices $319.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

DIO3 Antibody [DyLight 650] - NB110-96414C from Novus Biologicals

Prices $319.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
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