Gene Symbol | DIO3 |
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Entrez Gene | 1735 |
Alt Symbol | 5DIII, D3, DIOIII, TXDI3 |
Species | Human |
Gene Type | protein-coding |
Description | deiodinase, iodothyronine, type III |
Other Description | iodothyronine deiodinase, placental type|thyroxine deiodinase type III (selenoprotein)|type 3 DI|type 3 iodothyronine selenodeiodinase|type III iodothyronine deiodinase|type-III 5' deiodinase|type-III 5'-deiodinase |
Swissprots | P55073 Q8WVN5 G3XAM0 |
Accessions | EAW81747 P55073 AK292310 BAF84999 BC017717 AAH17717 BX161470 CAD61926 S79854 AAB35616 NM_001362 NP_001353 |
Function | Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine) into RT3 (3,3',5'-triiodothyronine) and of T3 (3,5,3'-triiodothyronine) into T2 (3,3'-diiodothyronine). RT3 and T2 are inactive metabolites. May play a role in preventing premature exposure of developing fetal tissues to adult levels of thyroid hormones. Can regulate circulating fetal thyroid hormone concentrations throughout gestation. Essential role for regulation of thyroid hormone inactivation during embryological development. {ECO:0000269|PubMed:7593630}. |
Subcellular Location | Cell membrane {ECO:0000269|PubMed:12419801}; Single-pass type II membrane protein {ECO:0000269|PubMed:12419801}. Endosome membrane {ECO:0000269|PubMed:12419801}; Single-pass type II membrane protein {ECO:0000269|PubMed:12419801}. |
Tissue Specificity | Expressed in placenta and several fetal tissues. |
DIO3 (A-19) - sc-69388 from Santa Cruz Biotechnology
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Anti-Dio3 antibody - ab102926 from Abcam
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Anti-Dio3 antibody - ab135860 from Abcam
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Anti-Dio3 antibody - ab82041 from Abcam
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Anti-DIO3 Antibody (aa250-278, AP) - LS-C256117 from LifeSpan Bioscience
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Anti-DIO3 Antibody (aa250-278, APC) - LS-C256118 from LifeSpan Bioscience
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Anti-DIO3 Antibody (aa250-278, FITC) - LS-C256119 from LifeSpan Bioscience
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Anti-DIO3 Antibody (aa250-278, PE) - LS-C256120 from LifeSpan Bioscience
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Anti-DIO3 Antibody (aa17-66) - LS-C199830 from LifeSpan Bioscience
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Anti-DIO3 Antibody (Glu66) - LS-C177532 from LifeSpan Bioscience
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Anti-DIO3 Antibody (aa249-278) - LS-C320845 from LifeSpan Bioscience
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Anti-DIO3 Antibody (aa250-278) - LS-C167418 from LifeSpan Bioscience
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DIO3 Antibody - NBP1-05767 from Novus Biologicals
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DIO3 Antibody - NB110-96414 from Novus Biologicals
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DIO3 Antibody [Biotin] - NBP1-05767B from Novus Biologicals
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DIO3 Antibody [FITC] - NB110-96414F from Novus Biologicals
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DIO3 Antibody [DyLight 405] - NB110-96414V from Novus Biologicals
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DIO3 Antibody [Alexa Fluor (R) 647] - NB110-96414AF647 from Novus Biologicals
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DIO3 Antibody [Alexa Fluor (R) 488] - NB110-96414AF488 from Novus Biologicals
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DIO3 Antibody [Alexa Fluor (R) 405] - NB110-96414AF405 from Novus Biologicals
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DIO3 Antibody [Alexa Fluor (R) 700] - NB110-96414AF700 from Novus Biologicals
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DIO3 Antibody [DyLight 488] - NBP1-05767G from Novus Biologicals
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DIO3 Antibody [DyLight 550] - NBP1-05767R from Novus Biologicals
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DIO3 Antibody [DyLight 550] - NB110-96414R from Novus Biologicals
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DIO3 Antibody [DyLight 650] - NB110-96414C from Novus Biologicals
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