| Gene Symbol |
DIO3
|
| Entrez Gene |
1735
|
| Alt Symbol |
5DIII, D3, DIOIII, TXDI3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
deiodinase, iodothyronine, type III
|
| Other Description |
iodothyronine deiodinase, placental type|thyroxine deiodinase type III (selenoprotein)|type 3 DI|type 3 iodothyronine selenodeiodinase|type III iodothyronine deiodinase|type-III 5' deiodinase|type-III 5'-deiodinase
|
| Swissprots |
P55073 Q8WVN5 G3XAM0
|
| Accessions |
EAW81747 P55073 AK292310 BAF84999 BC017717 AAH17717 BX161470 CAD61926 S79854 AAB35616 NM_001362 NP_001353
|
| Function |
Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine) into RT3 (3,3',5'-triiodothyronine) and of T3 (3,5,3'-triiodothyronine) into T2 (3,3'-diiodothyronine). RT3 and T2 are inactive metabolites. May play a role in preventing premature exposure of developing fetal tissues to adult levels of thyroid hormones. Can regulate circulating fetal thyroid hormone concentrations throughout gestation. Essential role for regulation of thyroid hormone inactivation during embryological development. {ECO:0000269|PubMed:7593630}.
|
| Subcellular Location |
Cell membrane {ECO:0000269|PubMed:12419801}; Single-pass type II membrane protein {ECO:0000269|PubMed:12419801}. Endosome membrane {ECO:0000269|PubMed:12419801}; Single-pass type II membrane protein {ECO:0000269|PubMed:12419801}.
|
| Tissue Specificity |
Expressed in placenta and several fetal tissues.
|