DIO3

Gene Symbol DIO3
Entrez Gene 1735
Alt Symbol 5DIII, D3, DIOIII, TXDI3
Species Human
Gene Type protein-coding
Description deiodinase, iodothyronine, type III
Other Description iodothyronine deiodinase, placental type|thyroxine deiodinase type III (selenoprotein)|type 3 DI|type 3 iodothyronine selenodeiodinase|type III iodothyronine deiodinase|type-III 5' deiodinase|type-III 5'-deiodinase
Swissprots P55073 Q8WVN5 G3XAM0
Accessions EAW81747 P55073 AK292310 BAF84999 BC017717 AAH17717 BX161470 CAD61926 S79854 AAB35616 NM_001362 NP_001353
Function Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine) into RT3 (3,3',5'-triiodothyronine) and of T3 (3,5,3'-triiodothyronine) into T2 (3,3'-diiodothyronine). RT3 and T2 are inactive metabolites. May play a role in preventing premature exposure of developing fetal tissues to adult levels of thyroid hormones. Can regulate circulating fetal thyroid hormone concentrations throughout gestation. Essential role for regulation of thyroid hormone inactivation during embryological development. {ECO:0000269|PubMed:7593630}.
Subcellular Location Cell membrane {ECO:0000269|PubMed:12419801}; Single-pass type II membrane protein {ECO:0000269|PubMed:12419801}. Endosome membrane {ECO:0000269|PubMed:12419801}; Single-pass type II membrane protein {ECO:0000269|PubMed:12419801}.
Tissue Specificity Expressed in placenta and several fetal tissues.

DIO3 CRISPR/Cas9 KO Plasmid (h) - sc-403729 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

DIO3 HDR Plasmid (h) - sc-403729-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

DIO3 Double Nickase Plasmid (h) - sc-403729-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

DIO3 Double Nickase Plasmid (h2) - sc-403729-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

DIO3 CRISPR Activation Plasmid (h) - sc-403729-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

DIO3 CRISPR Activation Plasmid (h2) - sc-403729-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

DIO3 Lentiviral Activation Particles (h) - sc-403729-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

DIO3 Lentiviral Activation Particles (h2) - sc-403729-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

DIO3 siRNA (h) - sc-77150 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

DIO3 shRNA Plasmid (h) - sc-77150-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

DIO3 shRNA (h) Lentiviral Particles - sc-77150-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU032841 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN7238 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7238 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

DIO3 siRNA (Human) - CRH1203 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

DIO3 - MBS8201129 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human DIO3 (NM_001362.3) - SHH278133 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human DIO3(NM_001362.3) - SHH005635 from Creative biogene

Category siRNA
Species Reactivities Human

Human DIO3 siRNA - orb261705 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

DIO3 shRNA Plasmid (Human) - CHH1203 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

DIO3 miRNA 3'UTR clone - MiUTR1H-02831 from Creative biogene

Species Reactivities Human
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