Gene Symbol | DIO3 |
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Entrez Gene | 1735 |
Alt Symbol | 5DIII, D3, DIOIII, TXDI3 |
Species | Human |
Gene Type | protein-coding |
Description | deiodinase, iodothyronine, type III |
Other Description | iodothyronine deiodinase, placental type|thyroxine deiodinase type III (selenoprotein)|type 3 DI|type 3 iodothyronine selenodeiodinase|type III iodothyronine deiodinase|type-III 5' deiodinase|type-III 5'-deiodinase |
Swissprots | P55073 Q8WVN5 G3XAM0 |
Accessions | EAW81747 P55073 AK292310 BAF84999 BC017717 AAH17717 BX161470 CAD61926 S79854 AAB35616 NM_001362 NP_001353 |
Function | Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine) into RT3 (3,3',5'-triiodothyronine) and of T3 (3,5,3'-triiodothyronine) into T2 (3,3'-diiodothyronine). RT3 and T2 are inactive metabolites. May play a role in preventing premature exposure of developing fetal tissues to adult levels of thyroid hormones. Can regulate circulating fetal thyroid hormone concentrations throughout gestation. Essential role for regulation of thyroid hormone inactivation during embryological development. {ECO:0000269|PubMed:7593630}. |
Subcellular Location | Cell membrane {ECO:0000269|PubMed:12419801}; Single-pass type II membrane protein {ECO:0000269|PubMed:12419801}. Endosome membrane {ECO:0000269|PubMed:12419801}; Single-pass type II membrane protein {ECO:0000269|PubMed:12419801}. |
Tissue Specificity | Expressed in placenta and several fetal tissues. |
DIO3 CRISPR/Cas9 KO Plasmid (h) - sc-403729 from Santa Cruz Biotechnology
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DIO3 HDR Plasmid (h) - sc-403729-HDR from Santa Cruz Biotechnology
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DIO3 Double Nickase Plasmid (h) - sc-403729-NIC from Santa Cruz Biotechnology
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DIO3 Double Nickase Plasmid (h2) - sc-403729-NIC-2 from Santa Cruz Biotechnology
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DIO3 CRISPR Activation Plasmid (h) - sc-403729-ACT from Santa Cruz Biotechnology
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DIO3 CRISPR Activation Plasmid (h2) - sc-403729-ACT-2 from Santa Cruz Biotechnology
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DIO3 Lentiviral Activation Particles (h) - sc-403729-LAC from Santa Cruz Biotechnology
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DIO3 Lentiviral Activation Particles (h2) - sc-403729-LAC-2 from Santa Cruz Biotechnology
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DIO3 siRNA (h) - sc-77150 from Santa Cruz Biotechnology
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DIO3 shRNA Plasmid (h) - sc-77150-SH from Santa Cruz Biotechnology
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DIO3 shRNA (h) Lentiviral Particles - sc-77150-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU032841 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN7238 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7238 from Sigma-Aldrich
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DIO3 siRNA (Human) - CRH1203 from Cohesion Biosciences
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DIO3 - MBS8201129 from MyBioSource
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shRNA set against Human DIO3 (NM_001362.3) - SHH278133 from Creative biogene
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shRNA set against Human DIO3(NM_001362.3) - SHH005635 from Creative biogene
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Human DIO3 siRNA - orb261705 from Biorbyt
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DIO3 shRNA Plasmid (Human) - CHH1203 from Cohesion Biosciences
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DIO3 miRNA 3'UTR clone - MiUTR1H-02831 from Creative biogene
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