DIO3

Gene Symbol	DIO3
Entrez Gene	1735
Alt Symbol	5DIII, D3, DIOIII, TXDI3
Species	Human
Gene Type	protein-coding
Description	deiodinase, iodothyronine, type III
Other Description	iodothyronine deiodinase, placental type|thyroxine deiodinase type III (selenoprotein)|type 3 DI|type 3 iodothyronine selenodeiodinase|type III iodothyronine deiodinase|type-III 5' deiodinase|type-III 5'-deiodinase
Swissprots	P55073 Q8WVN5 G3XAM0
Accessions	EAW81747 P55073 AK292310 BAF84999 BC017717 AAH17717 BX161470 CAD61926 S79854 AAB35616 NM_001362 NP_001353
Function	Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine) into RT3 (3,3',5'-triiodothyronine) and of T3 (3,5,3'-triiodothyronine) into T2 (3,3'-diiodothyronine). RT3 and T2 are inactive metabolites. May play a role in preventing premature exposure of developing fetal tissues to adult levels of thyroid hormones. Can regulate circulating fetal thyroid hormone concentrations throughout gestation. Essential role for regulation of thyroid hormone inactivation during embryological development. {ECO:0000269|PubMed:7593630}.
Subcellular Location	Cell membrane {ECO:0000269|PubMed:12419801}; Single-pass type II membrane protein {ECO:0000269|PubMed:12419801}. Endosome membrane {ECO:0000269|PubMed:12419801}; Single-pass type II membrane protein {ECO:0000269|PubMed:12419801}.
Tissue Specificity	Expressed in placenta and several fetal tissues.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Type III iodothyronine deiodinase, DIO3, Human, ELISA Kit - E12263h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t

Deiodinase, Iodothyronine, Type III, ELISA Kit - MBS088065 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Deiodinase, Iodothyronine, Type III, ELISA Kit - MBS108556 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.1 U/L. Range 0.625 U/L - 20 U/L.

Deiodinase, Iodothyronine, Type III, ELISA Kit - MBS105268 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.1 ng/ml. Range 0.5 ng/ml - 16 ng/ml.

Deiodinase, Iodothyronine, Type III, ELISA Kit - MBS061870 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Deiodinase, Iodothyronine, Type III, ELISA Kit - MBS079821 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Deiodinase, Iodothyronine, Type III, ELISA Kit - MBS107480 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Deiodinase, Iodothyronine, Type III, ELISA Kit - MBS048374 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Deiodinase, Iodothyronine, Type III (DIO3), ELISA Kit - MBS2024064 from MyBioSource Category ELISA Kit Prices $405.00, $605.00, $820.00, $3,375.00, $6,125.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity The minimum detectable dose of rat DIO3 is typically less than 0.117ng/mL. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined by adding two standard deviations to the mean optical density value of twenty zero standard replicates and calculating the corresponding concentration. Range 0.312-20ng/mL

Deiodinase, Iodothyronine, Type III (DIO3), ELISA Kit - MBS2018962 from MyBioSource Category ELISA Kit Prices $385.00, $575.00, $785.00, $3,210.00, $5,825.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity <0.115 ng/mL Range 0.312-20 ng/mL

ELISA Kit for Deiodinase, Iodothyronine, Type III (DIO3) - SEF989Mu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.115ng/mL. Range 0.313-20ng/mL The standard curve concentrations used for the ELISA’s were 20ng/mL, 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL

ELISA Kit for Deiodinase, Iodothyronine, Type III (DIO3) - SEF989Ra from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.117ng/mL. Range 0.313-20ng/mL The standard curve concentrations used for the ELISA’s were 20ng/mL, 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL

Human DIO3 ELISA Kit (Custom ELISA) - LS-F16512 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 0.313-20 ng/ml

Bovine DIO3 ELISA Kit (Custom ELISA) - LS-F16513 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Sensitivity To be determined Range 0.313-20 ng/ml

Human Type III iodothyronine deiodinase ELISA Kit - abx250676 from Abbexa Category ELISA Kit Range 0.312 ng/ml - 20 ng/ml

Human Type III iodothyronine deiodinase ELISA Kit - EKE53206 from Biomatik Category ELISA Kit Prices $685.40, $2,912.95, $5,483.20 Sizes 96 t, 5x96t, 10x96t Sensitivity The minimum detectable dose of this kit is typically less than 0.11 ng/ml Range 0.312-20 ng/mL

DIO3 - EKH2802 from Nordic BioSite Sensitivity 0.188ng/ml Range 0.312-20ng/ml

DIO3 ELISA Kit (Human) : 96 Wells (OKEH02219) - OKEH02219 from Aviva Systems Biology Category ELISA Kit Prices $420.00 Sizes 96 wells Sensitivity < 0.11 ng/mL Range 0.312 - 20 ng/mL

Human DIO3 ELISA Kit - E040106 from Biobool Category ELISA Kit Sensitivity <0.188ng/ml

Human Type III iodothyronine deiodinase ELISA Kit - EK3013 from Signalway Antibody Category ELISA Kit Prices $599.00 Sizes 1x96t Sensitivity less than 0.11ng/ml Range 0.312-20 ng/mL

Type III iodothyronine deiodinase, ELISA Kit - MBS2880290 from MyBioSource Category ELISA Kit Prices $380.00, $500.00, $2,170.00, $3,840.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Range 0.312-20 ng/mL

Type III iodothyronine deiodinase, ELISA Kit - MBS9426848 from MyBioSource Category ELISA Kit Prices $555.00 Sizes 96 tests Sensitivity Less than 0.11ng/mL Range 0.312-20 ng/mL

Deiodinase, Iodothyronine, Type III (DIO3), ELISA Kit - MBS9377894 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

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