DIO3

Gene Symbol	DIO3
Entrez Gene	1735
Alt Symbol	5DIII, D3, DIOIII, TXDI3
Species	Human
Gene Type	protein-coding
Description	deiodinase, iodothyronine, type III
Other Description	iodothyronine deiodinase, placental type|thyroxine deiodinase type III (selenoprotein)|type 3 DI|type 3 iodothyronine selenodeiodinase|type III iodothyronine deiodinase|type-III 5' deiodinase|type-III 5'-deiodinase
Swissprots	P55073 Q8WVN5 G3XAM0
Accessions	EAW81747 P55073 AK292310 BAF84999 BC017717 AAH17717 BX161470 CAD61926 S79854 AAB35616 NM_001362 NP_001353
Function	Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine) into RT3 (3,3',5'-triiodothyronine) and of T3 (3,5,3'-triiodothyronine) into T2 (3,3'-diiodothyronine). RT3 and T2 are inactive metabolites. May play a role in preventing premature exposure of developing fetal tissues to adult levels of thyroid hormones. Can regulate circulating fetal thyroid hormone concentrations throughout gestation. Essential role for regulation of thyroid hormone inactivation during embryological development. {ECO:0000269|PubMed:7593630}.
Subcellular Location	Cell membrane {ECO:0000269|PubMed:12419801}; Single-pass type II membrane protein {ECO:0000269|PubMed:12419801}. Endosome membrane {ECO:0000269|PubMed:12419801}; Single-pass type II membrane protein {ECO:0000269|PubMed:12419801}.
Tissue Specificity	Expressed in placenta and several fetal tissues.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Dio3 protein fragment - ab152332 from Abcam Category Protein Source Wheat germ Species Human

Human Dio3 protein fragment - ab152333 from Abcam Category Protein Source Wheat germ Species Human

DIO3 Antibody Blocking Peptide - LS-E10180 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

DIO3 Blocking Peptide - NB110-96414PEP from Novus Biologicals Category Peptide Prices $69.00 Sizes 50 µg Species Rat

DIO3 Blocking Peptide - NBP1-05767PEP from Novus Biologicals Category Peptide Prices $69.00 Sizes 50 µg Species Rat

Recombinant Human DIO3 Protein - H00001735-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Source Wheat Germ Species Human

DIO3 Partial Recombinant Protein - H00001735-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

DIO3-Antibody-C-term-Blocking-Peptide - BP9529b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

DIO3 Blocking Peptide - abx062538 from Abbexa Category Peptide Species Human, Mouse, Rat

DIO3 - H00001735-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

DIO3 - H00001735-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

Type III iodothyronine deiodinase - H00001735-P01-02 from Acris Antibodies Category Protein Prices $310.00 Sizes 2 µg Source in vitro transl. Species Human

Type III iodothyronine deiodinase - H00001735-P01-10 from Acris Antibodies Category Protein Prices $340.00 Sizes 10 µg Source in vitro transl. Species Human

Type III iodothyronine deiodinase - H00001735-P01-25 from Acris Antibodies Category Protein Prices $460.00 Sizes 25 µg Source in vitro transl. Species Human

DIO3 fusion protein - Ag24619 from Proteintech Group Category Protein Prices $199.00 Sizes 50 Source E. coli -derived, PET30a Species Human

Recombinant Deiodinase, Iodothyronine, Type III (DIO3) - RPF989Mu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

Recombinant Deiodinase, Iodothyronine, Type III (DIO3) - RPF989Mu02 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

Recombinant Deiodinase, Iodothyronine, Type III (DIO3) - RPF989Ra01 from Uscn Life Science Inc. Category Protein Source E.coli Species Rat

DIO3 Blocking Peptide - CBP1344 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat

DIO3 (E66) Peptide - BS3467P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Recombinant Protein D3(D3) - CSB-YP345746OEG CSB-EP345746OEG CSB-BP345746OEG CSB-MP345746OEG from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell

Recombinant Human Type III iodothyronine deiodinase(DIO3) - CSB-YP345038HU CSB-EP345038HU CSB-BP345038HU CSB-MP345038HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Recombinant Lithobates catesbeiana Type III iodothyronine deiodinase(dio3) - CSB-YP344229LQA CSB-EP344229LQA CSB-BP344229LQA CSB-MP344229LQA from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell

DIO3 Protein - abx163800 from Abbexa Category Protein Species Human

DIO3 Peptide, Human - M34GP04310H from Creative Peptides Category Peptide Source Synthetic. Species Human

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