| Gene Symbol | DCX |
|---|---|
| Entrez Gene | 1641 |
| Alt Symbol | DBCN, DC, LISX, SCLH, XLIS |
| Species | Human |
| Gene Type | protein-coding |
| Description | doublecortin |
| Other Description | doublecortex|doublin|lis-X|lissencephalin-X|neuronal migration protein doublecortin |
| Swissprots | Q5JYZ5 D3DUY9 O43911 D3DUY8 A6NFY6 O43602 A9Z1V8 D3DUZ0 |
| Accessions | CAA06617 EAX02642 EAX02643 EAX02644 EAX02645 EAX02646 EAX02647 EAX02648 EAX02649 O43602 AF034634 AAC52037 AF040254 AAC31797 AF040255 AAC31696 AJ003112 CAA05867 AK002120 AK290455 BAF83144 AK297297 BAG59765 AK299822 BAG61691 AU120758 AW163329 BC027925 AAH27925 DA497601 DC375659 HQ447825 ADQ32309 XM_011530878 XP_011529180 XM_011530879 XP_011529181 XM_011530880 XP_011529182 NM_000555 NP_000546 NM_001195553 NP_001182482 NM_178151 NP_835364 NM_178152 NP_835365 NM_178153 NP_835366 |
| Function | Microtubule-associated protein required for initial steps of neuronal dispersion and cortex lamination during cerebral cortex development. May act by competing with the putative neuronal protein kinase DCLK1 in binding to a target protein. May in that way participate in a signaling pathway that is crucial for neuronal interaction before and during migration, possibly as part of a calcium ion-dependent signal transduction pathway. May be part with PAFAH1B1/LIS-1 of overlapping, but distinct, signaling pathways that promote neuronal migration. {ECO:0000269|PubMed:22359282}. |
| Subcellular Location | Cytoplasm. Cell projection {ECO:0000250}. Note=Localizes at neurite tips. {ECO:0000250}. |
| Tissue Specificity | Highly expressed in neuronal cells of fetal brain (in the majority of cells of the cortical plate, intermediate zone and ventricular zone), but not expressed in other fetal tissues. In the adult, highly expressed in the brain frontal lobe, but very low expression in other regions of brain, and not detected in heart, placenta, lung, liver, skeletal muscles, kidney and pancreas. |