DCX

Gene Symbol	DCX
Entrez Gene	1641
Alt Symbol	DBCN, DC, LISX, SCLH, XLIS
Species	Human
Gene Type	protein-coding
Description	doublecortin
Other Description	doublecortex|doublin|lis-X|lissencephalin-X|neuronal migration protein doublecortin
Swissprots	Q5JYZ5 D3DUY9 O43911 D3DUY8 A6NFY6 O43602 A9Z1V8 D3DUZ0
Accessions	CAA06617 EAX02642 EAX02643 EAX02644 EAX02645 EAX02646 EAX02647 EAX02648 EAX02649 O43602 AF034634 AAC52037 AF040254 AAC31797 AF040255 AAC31696 AJ003112 CAA05867 AK002120 AK290455 BAF83144 AK297297 BAG59765 AK299822 BAG61691 AU120758 AW163329 BC027925 AAH27925 DA497601 DC375659 HQ447825 ADQ32309 XM_011530878 XP_011529180 XM_011530879 XP_011529181 XM_011530880 XP_011529182 NM_000555 NP_000546 NM_001195553 NP_001182482 NM_178151 NP_835364 NM_178152 NP_835365 NM_178153 NP_835366
Function	Microtubule-associated protein required for initial steps of neuronal dispersion and cortex lamination during cerebral cortex development. May act by competing with the putative neuronal protein kinase DCLK1 in binding to a target protein. May in that way participate in a signaling pathway that is crucial for neuronal interaction before and during migration, possibly as part of a calcium ion-dependent signal transduction pathway. May be part with PAFAH1B1/LIS-1 of overlapping, but distinct, signaling pathways that promote neuronal migration. {ECO:0000269|PubMed:22359282}.
Subcellular Location	Cytoplasm. Cell projection {ECO:0000250}. Note=Localizes at neurite tips. {ECO:0000250}.
Tissue Specificity	Highly expressed in neuronal cells of fetal brain (in the majority of cells of the cortical plate, intermediate zone and ventricular zone), but not expressed in other fetal tissues. In the adult, highly expressed in the brain frontal lobe, but very low expression in other regions of brain, and not detected in heart, placenta, lung, liver, skeletal muscles, kidney and pancreas.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Doublecortin peptide - ab19804 from Abcam Category Peptide

Mouse Doublecortin (phospho S28) peptide - ab31511 from Abcam Category Peptide

Mouse Doublecortin (phospho S297) peptide - ab31731 from Abcam Category Peptide

Mouse Doublecortin peptide - ab31512 from Abcam Category Peptide

Mouse Doublecortin peptide - ab31732 from Abcam Category Peptide

Rat Doublecortin peptide - ab19803 from Abcam Category Peptide

DCX / Doublecortin Antibody Blocking Peptide - LS-E27631 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

DCX / Doublecortin Antibody Blocking Peptide - LS-E7084 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

DCX / Doublecortin Antibody Blocking Peptide - LS-E15201 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

DCX / Doublecortin Antibody Blocking Peptide - LS-E15202 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

DCX / Doublecortin Antibody Blocking Peptide - LS-E27939 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human Doublecortin Protein - H00001641-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

DCX-Antibody-S128-Blocking-Peptide - BP2768a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

DCX Protein Lysate (APL10309) - APL10309 from Aviva Systems Biology Category Protein Prices $219.00 Sizes 200 µg

DCX Protein Lysate (APL10310) - APL10310 from Aviva Systems Biology Category Protein Prices $219.00 Sizes 200 µg

Doublecortin protein - orb245616 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg

Human DCX protein (GST Tag) - orb138687 from Biorbyt Category Protein Prices $298.00, $434.00 Sizes 20 μg, 50 μg Source E. coli Species Human

Goat anti Dcx antibody Immunizing peptide - orb66414 from Biorbyt Category Peptide Prices $247.00 Sizes 100 μg Species Human, Mouse, Rat

DCX Immunizing peptide - orb66202 from Biorbyt Category Peptide Prices $247.00 Sizes 100 μg Species Human, Mouse, Rat

DCX Blocking Peptide - 33R-8973 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

DCX Blocking Peptide - 33R-7047 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

Doublecortin Peptide - AC21-2449-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

Doublecortin Peptide - AC21-2708-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

Doublecortin - H00001641-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

Doublecortin - H00001641-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

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