PLK1
| Gene Symbol | PLK1 |
|---|---|
| Entrez Gene | 5347 |
| Alt Symbol | PLK, STPK13 |
| Species | Human |
| Gene Type | protein-coding |
| Description | polo-like kinase 1 |
| Other Description | PLK-1|cell cycle regulated protein kinase|polo (Drosophia)-like kinase|polo like kinase|serine/threonine-protein kinase 13|serine/threonine-protein kinase PLK1 |
| Swissprots | P53350 Q99746 Q15153 |
| Accessions | AAB36946 CAA62260 CAS92530 CAT02195 EAW55803 EAW55804 EAW55805 EAW55806 P53350 AB084459 BAD93352 AB209179 BAD92416 AK303263 BAG64345 AK308276 AK313227 BAG36038 BC002369 AAH02369 BC003002 AAH03002 BC014846 AAH14846 DQ891045 ABM81971 DQ894224 ABM85150 L19559 AAA36659 U01038 AAA56634 X73458 CAA51837 X75932 CAA53536 NM_005030 NP_005021 |
| Function | Serine/threonine-protein kinase that performs several important functions throughout M phase of the cell cycle, including the regulation of centrosome maturation and spindle assembly, the removal of cohesins from chromosome arms, the inactivation of anaphase-promoting complex/cyclosome (APC/C) inhibitors, and the regulation of mitotic exit and cytokinesis. Polo-like kinase proteins acts by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates BORA, BUB1B/BUBR1, CCNB1, CDC25C, CEP55, ECT2, ERCC6L, FBXO5/EMI1, FOXM1, KIF20A/MKLP2, CENPU, NEDD1, NINL, NPM1, NUDC, PKMYT1/MYT1, KIZ, PPP1R12A/MYPT1, PRC1, RACGAP1/CYK4, SGOL1, STAG2/SA2, TEX14, TOPORS, p73/TP73, TPT1 and WEE1. Plays a key role in centrosome functions and the assembly of bipolar spindles by phosphorylating KIZ, NEDD1 and NINL. NEDD1 phosphorylation promotes subsequent targeting of the gamma-tubulin ring complex (gTuRC) to the centrosome, an i |
| Subcellular Location | Nucleus. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Midbody. Note=During early stages of mitosis, the phosphorylated form is detected on centrosomes and kinetochores. Localizes to the outer kinetochore. Presence of SGOL1 and interaction with the phosphorylated form of BUB1 is required for the kinetochore localization. Localizes onto the central spindle by phosphorylating and docking at midzone proteins KIF20A/MKLP2 and PRC1. Colocalizes with FRY to separating centrosomes and spindle poles from prophase to metaphase in mitosis, but not in other stages of the cell cycle. |
| Tissue Specificity | Placenta and colon. |
| Top Pathways | Cell cycle, Progesterone-mediated oocyte maturation, Oocyte meiosis |
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