PLK1

Gene Symbol	PLK1
Entrez Gene	5347
Alt Symbol	PLK, STPK13
Species	Human
Gene Type	protein-coding
Description	polo-like kinase 1
Other Description	PLK-1|cell cycle regulated protein kinase|polo (Drosophia)-like kinase|polo like kinase|serine/threonine-protein kinase 13|serine/threonine-protein kinase PLK1
Swissprots	P53350 Q99746 Q15153
Accessions	AAB36946 CAA62260 CAS92530 CAT02195 EAW55803 EAW55804 EAW55805 EAW55806 P53350 AB084459 BAD93352 AB209179 BAD92416 AK303263 BAG64345 AK308276 AK313227 BAG36038 BC002369 AAH02369 BC003002 AAH03002 BC014846 AAH14846 DQ891045 ABM81971 DQ894224 ABM85150 L19559 AAA36659 U01038 AAA56634 X73458 CAA51837 X75932 CAA53536 NM_005030 NP_005021
Function	Serine/threonine-protein kinase that performs several important functions throughout M phase of the cell cycle, including the regulation of centrosome maturation and spindle assembly, the removal of cohesins from chromosome arms, the inactivation of anaphase-promoting complex/cyclosome (APC/C) inhibitors, and the regulation of mitotic exit and cytokinesis. Polo-like kinase proteins acts by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates BORA, BUB1B/BUBR1, CCNB1, CDC25C, CEP55, ECT2, ERCC6L, FBXO5/EMI1, FOXM1, KIF20A/MKLP2, CENPU, NEDD1, NINL, NPM1, NUDC, PKMYT1/MYT1, KIZ, PPP1R12A/MYPT1, PRC1, RACGAP1/CYK4, SGOL1, STAG2/SA2, TEX14, TOPORS, p73/TP73, TPT1 and WEE1. Plays a key role in centrosome functions and the assembly of bipolar spindles by phosphorylating KIZ, NEDD1 and NINL. NEDD1 phosphorylation promotes subsequent targeting of the gamma-tubulin ring complex (gTuRC) to the centrosome, an i
Subcellular Location	Nucleus. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Midbody. Note=During early stages of mitosis, the phosphorylated form is detected on centrosomes and kinetochores. Localizes to the outer kinetochore. Presence of SGOL1 and interaction with the phosphorylated form of BUB1 is required for the kinetochore localization. Localizes onto the central spindle by phosphorylating and docking at midzone proteins KIF20A/MKLP2 and PRC1. Colocalizes with FRY to separating centrosomes and spindle poles from prophase to metaphase in mitosis, but not in other stages of the cell cycle.
Tissue Specificity	Placenta and colon.
Top Pathways	Cell cycle, Progesterone-mediated oocyte maturation, Oocyte meiosis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human PLK1 full length protein - ab51426 from Abcam Category Protein Prices $302.00, $1,845.00 Sizes 10 µg, 100 µg Source Baculovirus infected sf9 cells Species Human

Human PLK1 (phospho S137) peptide - ab25712 from Abcam Category Peptide

Human PLK1 full length protein - ab82064 from Abcam Category Protein Source Baculovirus Species Human

Human PLK1 protein fragment - ab152617 from Abcam Category Protein Source Wheat germ Species Human

Human PLK1 protein fragment - ab196403 from Abcam Category Protein Source E. coli Species Human

PLK1 peptide - ab25713 from Abcam Category Peptide

PLK1 / PLK-1 Antibody Blocking Peptide - LS-E16815 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PLK1 / PLK-1 Antibody Blocking Peptide - LS-E16816 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PLK1 / PLK-1 Antibody Blocking Peptide - LS-E9382 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PLK1 / PLK-1 Antibody Blocking Peptide - LS-E27892 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PLK1 Partial Recombinant Protein - H00005347-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

PLK1 Recombinant Protein - H00005347-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

PLK1 Recombinant Protein - P3894 from Novus Biologicals Category Protein Prices $1,559.00 Sizes 5 µg Species Human

Recombinant Human PLK1 Protein - P4765 from Novus Biologicals Category Protein Prices $1,559.00 Sizes 100 µg Source Insect Species Human

PLK1 Peptide - P2920 from Novus Biologicals Category Peptide Species Human

PLK1-Antibody-C-term-Blocking-Peptide - BP7937a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant Human Active PLK1, CF - 3804-KS-010 from R&D Systems Category Protein

PLK1 Protein Lysate (APL10299) - APL10299 from Aviva Systems Biology Category Protein Prices $219.00 Sizes 200 µg

PLK1 Protein Lysate (APL10458) - APL10458 from Aviva Systems Biology Category Protein Prices $219.00 Sizes 200 µg

PLK1 Protein Lysate (APL10459) - APL10459 from Aviva Systems Biology Category Protein Prices $219.00 Sizes 200 µg

Human PLK 1 protein - orb83438 from Biorbyt Category Protein Prices $323.00, $400.00 Sizes 20 μg, 10 μg Source Insect Species Human

PLK1 Blocking Peptide - 33R-4619 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

PLK1 (phospho-Thr210) Blocking Peptide - abx062185 from Abbexa Category Peptide Species Human, Bovine, Monkey, Pig, Zebrafish

PLK1 Peptide - AC21-2889-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

PLK1 - H00005347-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

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