PLK1

Gene Symbol	PLK1
Entrez Gene	5347
Alt Symbol	PLK, STPK13
Species	Human
Gene Type	protein-coding
Description	polo-like kinase 1
Other Description	PLK-1|cell cycle regulated protein kinase|polo (Drosophia)-like kinase|polo like kinase|serine/threonine-protein kinase 13|serine/threonine-protein kinase PLK1
Swissprots	P53350 Q99746 Q15153
Accessions	AAB36946 CAA62260 CAS92530 CAT02195 EAW55803 EAW55804 EAW55805 EAW55806 P53350 AB084459 BAD93352 AB209179 BAD92416 AK303263 BAG64345 AK308276 AK313227 BAG36038 BC002369 AAH02369 BC003002 AAH03002 BC014846 AAH14846 DQ891045 ABM81971 DQ894224 ABM85150 L19559 AAA36659 U01038 AAA56634 X73458 CAA51837 X75932 CAA53536 NM_005030 NP_005021
Function	Serine/threonine-protein kinase that performs several important functions throughout M phase of the cell cycle, including the regulation of centrosome maturation and spindle assembly, the removal of cohesins from chromosome arms, the inactivation of anaphase-promoting complex/cyclosome (APC/C) inhibitors, and the regulation of mitotic exit and cytokinesis. Polo-like kinase proteins acts by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates BORA, BUB1B/BUBR1, CCNB1, CDC25C, CEP55, ECT2, ERCC6L, FBXO5/EMI1, FOXM1, KIF20A/MKLP2, CENPU, NEDD1, NINL, NPM1, NUDC, PKMYT1/MYT1, KIZ, PPP1R12A/MYPT1, PRC1, RACGAP1/CYK4, SGOL1, STAG2/SA2, TEX14, TOPORS, p73/TP73, TPT1 and WEE1. Plays a key role in centrosome functions and the assembly of bipolar spindles by phosphorylating KIZ, NEDD1 and NINL. NEDD1 phosphorylation promotes subsequent targeting of the gamma-tubulin ring complex (gTuRC) to the centrosome, an i
Subcellular Location	Nucleus. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Midbody. Note=During early stages of mitosis, the phosphorylated form is detected on centrosomes and kinetochores. Localizes to the outer kinetochore. Presence of SGOL1 and interaction with the phosphorylated form of BUB1 is required for the kinetochore localization. Localizes onto the central spindle by phosphorylating and docking at midzone proteins KIF20A/MKLP2 and PRC1. Colocalizes with FRY to separating centrosomes and spindle poles from prophase to metaphase in mitosis, but not in other stages of the cell cycle.
Tissue Specificity	Placenta and colon.
Top Pathways	Cell cycle, Progesterone-mediated oocyte maturation, Oocyte meiosis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Mouse/Human/Rat Phospho-PLK1 / PLK-1 (Ser137) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1699 from LifeSpan Bioscience Category ELISA Kit Prices $550.00 Sizes 1 plate

Mouse/Human/Rat PLK1 / PLK-1 ELISA Kit (Cell-Based ELISA) - LS-F2261 from LifeSpan Bioscience Category ELISA Kit Prices $450.00 Sizes 1 plate

Rabbit anti-PLK1 Antibody, Affinity Purified - PLA0073 from Sigma-Aldrich Prices $323.50 Sizes 100 µl

Serine/threonine-protein kinase PLK1 (PLK1), Human, ELISA Kit - CSB-EL018193HU from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

Serine/threonine-protein kinase PLK1, PLK1, Human, ELISA Kit - E1662h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t Range 7.8-500 pg/mL

PLK1 (Human) IP-WB Antibody Pair - H00005347-PW1 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

PLK1 (Human) IP-WB Antibody Pair - H00005347-PW2 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

Phospho-Polo-like kinase 1 (P-PLK1), ELISA Kit - MBS9313347 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

PLK1 Colorimetric Cell-Based ELISA Kit - CB5577 from Assay Biotechnology Category ELISA Kit Prices $380.00, $760.00, $1,140.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

PLK1 (Phospho-Ser137) Colorimetric Cell-Based ELISA Kit - CBP1769 from Assay Biotechnology Category ELISA Kit Prices $480.00, $960.00, $1,440.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

polo-like kinase 1 (Drosophila) , ELISA Kit - MBS946330 from MyBioSource Category ELISA Kit Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity The minimum detectable dose of human PLK1 is typically less than 9.77 pg/ml. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mean O.D value of 20 replicates of the zero standard added by their three standard deviations. Range 39 pg/ml -2500 pg/ml.

Survivin Antibody, ELISA Kit - MBS042244 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Survivin Antibody, ELISA Kit - MBS092946 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Survivin Antibody, ELISA Kit - MBS013075 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Survivin Antibody, ELISA Kit - MBS021274 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Survivin Antibody, ELISA Kit - MBS040496 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Survivin Antibody, ELISA Kit - MBS024118 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Survivin Antibody, ELISA Kit - MBS011075 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Survivin Antibody, ELISA Kit - MBS032082 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Survivin Antibody, ELISA Kit - MBS104020 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Survivin Antibody, ELISA Kit - MBS105571 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Survivin Antibody, ELISA Kit - MBS028283 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Survivin Antibody, ELISA Kit - MBS021381 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Survivin Antibody, ELISA Kit - MBS035259 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Survivin Antibody, ELISA Kit - MBS021446 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

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