PRUNE

Gene Symbol	PRUNE
Entrez Gene	58497
Alt Symbol	DRES-17, DRES17, HTCD37
Species	Human
Gene Type	protein-coding
Description	prune exopolyphosphatase
Other Description	Drosophila-related expressed sequence 17|protein prune homolog
Swissprots	B2RCH8 Q96JU5 Q5SZF9 B4DFL7 Q9UIV0 Q9C072 Q8N654 Q659E5 Q9C071 Q86TP1 Q6P4E0
Accessions	EAW53485 EAW53486 EAW53487 EAW53488 EAW53489 EAW53490 Q86TP1 AF051907 AAC95290 AF123538 AAK00592 AF123539 AAK00593 AK027875 BAB55423 AK294154 BAG57478 AK298273 BAG60534 AK315120 BAG37575 AK316537 BAH14908 AL122054 CAH56396 AL137324 BC014886 AAH14886 BC017755 BC025304 AAH25304 BC063481 AAH63481 BM554427 DA719664 DA942287 DQ892819 ABM83745 DQ896065 ABM87064 U67085 AAF04914 XM_005245393 XP_005245450 XM_005245397 XP_005245454 XM_011509830 XP_011508132 XM_011509831 XP_011508133 XM_011509832 XP_011508134 NM_001303229 NP_001290158 NM_001303242 NP_001290171 NM_001303243 NP_001290172 NM_021222 NP_067045 NR_130130 NR_130131 NR_130132 NR_130135
Function	Phosphodiesterase (PDE) that has higher activity toward cAMP than cGMP, as substrate. Plays a role in cell proliferation, is able to induce cell motility and acts as a negative regulator of NME1. {ECO:0000269|PubMed:10602478, ECO:0000269|PubMed:11687967, ECO:0000269|PubMed:14998490, ECO:0000269|PubMed:16428445, ECO:0000269|PubMed:17906697}.
Subcellular Location	Cytoplasm. Nucleus. Cell junction, focal adhesion. Note=In some transfected cells a nuclear staining is also observed.
Tissue Specificity	Ubiquitously expressed. Seems to be overexpressed in aggressive sarcoma subtypes, such as leiomyosarcomas and malignant fibrous histiocytomas (MFH) as well as in the less malignant liposarcomas. {ECO:0000269|PubMed:10602478, ECO:0000269|PubMed:11687967, ECO:0000269|PubMed:15671547}.
Top Pathways	Purine metabolism

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

h-prune (F-5) - sc-393318 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

h-prune (D-14) - sc-69179 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

h-prune (G-17) - sc-69180 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

h-prune (H-53) - sc-292162 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

Anti-PRUNE antibody - ab88613 from Abcam Prices $370.00 Sizes 50 µg Host Mouse Clonality Polyclonal

Anti-PRUNE antibody - ab102945 from Abcam Prices $359.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-PRUNE antibody [1C11] - ab129296 from Abcam Prices $407.00 Sizes 50 µg Host Mouse Clonality Monoclonal Clone 1C11

Anti-PRUNE antibody - C-terminal - ab191162 from Abcam Prices $407.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-PRUNE Antibody - LS-C9805 from LifeSpan Bioscience Prices $435.00 Sizes 50 µg Host Mouse Clonality Monoclonal

Anti-PRUNE Antibody (aa367-397, AP) - LS-C223780 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-PRUNE Antibody (aa367-397, APC) - LS-C223781 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-PRUNE Antibody (aa367-397, Biotin) - LS-C223782 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-PRUNE Antibody (aa367-397, FITC) - LS-C223783 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-PRUNE Antibody (aa367-397, Azide-free, HRP) - LS-C223784 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-PRUNE Antibody (aa367-397, PE) - LS-C223786 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-PRUNE Antibody (aa367-397) - LS-C324341 from LifeSpan Bioscience Prices $345.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-PRUNE Antibody (C-Terminus) - LS-C201703 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-PRUNE Antibody (C-Terminus) - LS-C345704 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-PRUNE Antibody (clone 1C11) IHC-plus™ - LS-B6393 from LifeSpan Bioscience Prices $450.00 Sizes 50 µg Host Mouse Clonality Monoclonal Clone 1C11

Anti-PRUNE Antibody (aa360-389) IHC-plus™ - LS-B10719 from LifeSpan Bioscience Prices $395.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

PRUNE Antibody - NBP1-84055 from Novus Biologicals Prices $419.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

PRUNE Antibody - H00058497-B01P from Novus Biologicals Prices $359.00 Sizes 50 µg Host Mouse Clonality Polyclonal

PRUNE Antibody (1C11) - H00058497-M01 from Novus Biologicals Prices $359.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 1C11

PRUNE Antibody - H00058497-D01P from Novus Biologicals Prices $399.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

DRES17 Polyclonal Antibody - bs-6299R from Bioss Prices $269.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

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