PRUNE

Gene Symbol	PRUNE
Entrez Gene	58497
Alt Symbol	DRES-17, DRES17, HTCD37
Species	Human
Gene Type	protein-coding
Description	prune exopolyphosphatase
Other Description	Drosophila-related expressed sequence 17|protein prune homolog
Swissprots	B2RCH8 Q96JU5 Q5SZF9 B4DFL7 Q9UIV0 Q9C072 Q8N654 Q659E5 Q9C071 Q86TP1 Q6P4E0
Accessions	EAW53485 EAW53486 EAW53487 EAW53488 EAW53489 EAW53490 Q86TP1 AF051907 AAC95290 AF123538 AAK00592 AF123539 AAK00593 AK027875 BAB55423 AK294154 BAG57478 AK298273 BAG60534 AK315120 BAG37575 AK316537 BAH14908 AL122054 CAH56396 AL137324 BC014886 AAH14886 BC017755 BC025304 AAH25304 BC063481 AAH63481 BM554427 DA719664 DA942287 DQ892819 ABM83745 DQ896065 ABM87064 U67085 AAF04914 XM_005245393 XP_005245450 XM_005245397 XP_005245454 XM_011509830 XP_011508132 XM_011509831 XP_011508133 XM_011509832 XP_011508134 NM_001303229 NP_001290158 NM_001303242 NP_001290171 NM_001303243 NP_001290172 NM_021222 NP_067045 NR_130130 NR_130131 NR_130132 NR_130135
Function	Phosphodiesterase (PDE) that has higher activity toward cAMP than cGMP, as substrate. Plays a role in cell proliferation, is able to induce cell motility and acts as a negative regulator of NME1. {ECO:0000269|PubMed:10602478, ECO:0000269|PubMed:11687967, ECO:0000269|PubMed:14998490, ECO:0000269|PubMed:16428445, ECO:0000269|PubMed:17906697}.
Subcellular Location	Cytoplasm. Nucleus. Cell junction, focal adhesion. Note=In some transfected cells a nuclear staining is also observed.
Tissue Specificity	Ubiquitously expressed. Seems to be overexpressed in aggressive sarcoma subtypes, such as leiomyosarcomas and malignant fibrous histiocytomas (MFH) as well as in the less malignant liposarcomas. {ECO:0000269|PubMed:10602478, ECO:0000269|PubMed:11687967, ECO:0000269|PubMed:15671547}.
Top Pathways	Purine metabolism

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Protein prune homolog (PRUNE), Human, ELISA Kit - CSB-EL018831HU from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

prune homolog (Drosophila) , ELISA Kit - MBS946942 from MyBioSource Category ELISA Kit Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity The minimum detectable dose of human PRUNE is typically less than 11.75 pg/ml. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mean O.D value of 20 replicates of the zero standard added by their three standard deviations. Range 47 pg/ml -3000 pg/ml.

Human Protein prune homolog(PRUNE) ELISA kit - CSB-EL018831HU from Cusabio Category ELISA Kit Sensitivity 11.75 pg/ml Range 47 pg/ml-3000 pg/ml

Human PRUNE ELISA Kit - E032225 from Biobool Category ELISA Kit Sensitivity The minimum detectable dose of human PRUNE is typically less than 11.75 pg/ml. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the m

PRUNE ELISA Kit (Human) (OKCA00782) - OKCA00782 from Aviva Systems Biology Category ELISA Kit Prices $590.00 Sizes 96 wells Sensitivity 11.75 pg/mL Range 47 pg/mL-3,000 pg/mL

Human Protein prune homolog (PRUNE) ELISA Kit - AE25588HU from ARP American Research Products Category ELISA Kit Prices $549.00 Sizes 96 t Sensitivity 11.75 pg/mL Range 47-3000 pg/mL

Human PRUNE ELISA Kit - orb405130 from Biorbyt Category ELISA Kit Sensitivity 11.75 pg/ml Range 47 pg/ml-3000 pg/ml

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