PRUNE

Gene Symbol PRUNE
Entrez Gene 58497
Alt Symbol DRES-17, DRES17, HTCD37
Species Human
Gene Type protein-coding
Description prune exopolyphosphatase
Other Description Drosophila-related expressed sequence 17|protein prune homolog
Swissprots B2RCH8 Q96JU5 Q5SZF9 B4DFL7 Q9UIV0 Q9C072 Q8N654 Q659E5 Q9C071 Q86TP1 Q6P4E0
Accessions EAW53485 EAW53486 EAW53487 EAW53488 EAW53489 EAW53490 Q86TP1 AF051907 AAC95290 AF123538 AAK00592 AF123539 AAK00593 AK027875 BAB55423 AK294154 BAG57478 AK298273 BAG60534 AK315120 BAG37575 AK316537 BAH14908 AL122054 CAH56396 AL137324 BC014886 AAH14886 BC017755 BC025304 AAH25304 BC063481 AAH63481 BM554427 DA719664 DA942287 DQ892819 ABM83745 DQ896065 ABM87064 U67085 AAF04914 XM_005245393 XP_005245450 XM_005245397 XP_005245454 XM_011509830 XP_011508132 XM_011509831 XP_011508133 XM_011509832 XP_011508134 NM_001303229 NP_001290158 NM_001303242 NP_001290171 NM_001303243 NP_001290172 NM_021222 NP_067045 NR_130130 NR_130131 NR_130132 NR_130135
Function Phosphodiesterase (PDE) that has higher activity toward cAMP than cGMP, as substrate. Plays a role in cell proliferation, is able to induce cell motility and acts as a negative regulator of NME1. {ECO:0000269|PubMed:10602478, ECO:0000269|PubMed:11687967, ECO:0000269|PubMed:14998490, ECO:0000269|PubMed:16428445, ECO:0000269|PubMed:17906697}.
Subcellular Location Cytoplasm. Nucleus. Cell junction, focal adhesion. Note=In some transfected cells a nuclear staining is also observed.
Tissue Specificity Ubiquitously expressed. Seems to be overexpressed in aggressive sarcoma subtypes, such as leiomyosarcomas and malignant fibrous histiocytomas (MFH) as well as in the less malignant liposarcomas. {ECO:0000269|PubMed:10602478, ECO:0000269|PubMed:11687967, ECO:0000269|PubMed:15671547}.
Top Pathways Purine metabolism

h-prune CRISPR/Cas9 KO Plasmid (h) - sc-412914 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

h-prune HDR Plasmid (h) - sc-412914-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

h-prune Double Nickase Plasmid (h) - sc-412914-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

h-prune Double Nickase Plasmid (h2) - sc-412914-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

h-prune CRISPR Activation Plasmid (h) - sc-412914-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

h-prune CRISPR Activation Plasmid (h2) - sc-412914-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

h-prune Lentiviral Activation Particles (h) - sc-412914-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

h-prune Lentiviral Activation Particles (h2) - sc-412914-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

h-prune siRNA (h) - sc-75218 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

h-prune shRNA Plasmid (h) - sc-75218-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

h-prune shRNA (h) Lentiviral Particles - sc-75218-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU069081 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN17556 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17556 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR09607 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr09607

PRUNE siRNA (Human) - CRJ1727 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human PRUNE (NM_021222.1) - SHH384720 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human PRUNE(NM_021222.1) - SHR145136 from Creative biogene

Category siRNA
Species Reactivities Human

Human PRUNE siRNA - orb272228 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

PRUNE shRNA Plasmid (Human) - CHJ1727 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

PRUNE miRNA 3'UTR clone - MiUTR1H-08345 from Creative biogene

Species Reactivities Human
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