PRUNE

Gene Symbol	PRUNE
Entrez Gene	58497
Alt Symbol	DRES-17, DRES17, HTCD37
Species	Human
Gene Type	protein-coding
Description	prune exopolyphosphatase
Other Description	Drosophila-related expressed sequence 17|protein prune homolog
Swissprots	B2RCH8 Q96JU5 Q5SZF9 B4DFL7 Q9UIV0 Q9C072 Q8N654 Q659E5 Q9C071 Q86TP1 Q6P4E0
Accessions	EAW53485 EAW53486 EAW53487 EAW53488 EAW53489 EAW53490 Q86TP1 AF051907 AAC95290 AF123538 AAK00592 AF123539 AAK00593 AK027875 BAB55423 AK294154 BAG57478 AK298273 BAG60534 AK315120 BAG37575 AK316537 BAH14908 AL122054 CAH56396 AL137324 BC014886 AAH14886 BC017755 BC025304 AAH25304 BC063481 AAH63481 BM554427 DA719664 DA942287 DQ892819 ABM83745 DQ896065 ABM87064 U67085 AAF04914 XM_005245393 XP_005245450 XM_005245397 XP_005245454 XM_011509830 XP_011508132 XM_011509831 XP_011508133 XM_011509832 XP_011508134 NM_001303229 NP_001290158 NM_001303242 NP_001290171 NM_001303243 NP_001290172 NM_021222 NP_067045 NR_130130 NR_130131 NR_130132 NR_130135
Function	Phosphodiesterase (PDE) that has higher activity toward cAMP than cGMP, as substrate. Plays a role in cell proliferation, is able to induce cell motility and acts as a negative regulator of NME1. {ECO:0000269|PubMed:10602478, ECO:0000269|PubMed:11687967, ECO:0000269|PubMed:14998490, ECO:0000269|PubMed:16428445, ECO:0000269|PubMed:17906697}.
Subcellular Location	Cytoplasm. Nucleus. Cell junction, focal adhesion. Note=In some transfected cells a nuclear staining is also observed.
Tissue Specificity	Ubiquitously expressed. Seems to be overexpressed in aggressive sarcoma subtypes, such as leiomyosarcomas and malignant fibrous histiocytomas (MFH) as well as in the less malignant liposarcomas. {ECO:0000269|PubMed:10602478, ECO:0000269|PubMed:11687967, ECO:0000269|PubMed:15671547}.
Top Pathways	Purine metabolism

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human-PRUNE-cDNA-Clone - DC03951 from Abgent, a WuXi AppTec company Prices $226.80 Sizes 10 µg Species Human Accession BC063481

PRUNE - MBS1272232 from MyBioSource Prices $175.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC063481

PRUNE - MBS1276400 from MyBioSource Species Human Accession BC014886

Human PRUNE cDNA clone(NM_021222.1) - CDFG003292 from Creative Biomart Species Human Accession NM_021222.1

Human PRUNE ORF Clone(NM_021222.1) - CDCR306840 from Creative Biomart Species Human Accession NM_021222.1

Human PRUNE ORF Clone(NM_021222.1) - CDCR306841 from Creative Biomart Species Human Accession NM_021222.1

Human PRUNE Gene cDNA Clone (full-length ORF Clone) - HG16167-G from Sino Biological Species Human Accession AK315120.1

Human PRUNE natural ORF mammalian expression plasmid, N-HA tag - HG16167-NY from Sino Biological Species Human Accession AK315120.1

Human PRUNE Gene cDNA Clone (full-length ORF Clone), expression ready, C-His-tagged - HG16167-CH from Sino Biological Species Human Accession AK315120.1

Human PRUNE Gene cDNA Clone (full-length ORF Clone), expression ready, C-OFPSpark tag - HG16167-ACR from Sino Biological Species Human Accession AK315120.1

Human PRUNE Gene cDNA Clone (full-length ORF Clone), expression ready, N-OFPSpark tag - HG16167-ANR from Sino Biological Species Human Accession AK315120.1

Human PRUNE Gene cDNA Clone (full-length ORF Clone), expression ready, N-FLAG-tagged - HG16167-NF from Sino Biological Species Human Accession AK315120.1

Human PRUNE Gene cDNA Clone (full-length ORF Clone), expression ready, untagged - HG16167-UT from Sino Biological Species Human Accession AK315120.1

Human PRUNE Gene cDNA Clone (full-length ORF Clone), expression ready, C-FLAG-tagged - HG16167-CF from Sino Biological Species Human Accession AK315120.1

Human PRUNE Gene cDNA Clone (full-length ORF Clone), expression ready, N-Myc-tagged - HG16167-NM from Sino Biological Species Human Accession AK315120.1

Human PRUNE Gene cDNA Clone (full-length ORF Clone), expression ready, C-Myc-tagged - HG16167-CM from Sino Biological Species Human Accession AK315120.1

Human PRUNE Gene cDNA Clone (full-length ORF Clone), expression ready, N-His-tagged - HG16167-NH from Sino Biological Species Human Accession AK315120.1

Human PRUNE Gene cDNA Clone (full-length ORF Clone), expression ready, C-HA-tagged - HG16167-CY from Sino Biological Species Human Accession AK315120.1

Human PRUNE Gene cDNA Clone (full-length ORF Clone), expression ready, C-GFPSpark-tagged - HG16167-ACG from Sino Biological Species Human Accession AK315120.1

Human PRUNE Gene cDNA Clone (full-length ORF Clone), expression ready, N-GFPSpark-tagged - HG16167-ANG from Sino Biological Species Human Accession AK315120.1

Human PRUNE ORF Clone(NM_021222.1) - CDCR306840 from Creative biogene Species Human

Human PRUNE ORF Clone (BC063481) - CDCS415321 from Creative biogene Species Human Accession Q86TP1

Human PRUNE ORF Clone (BC014886) - CDCS415322 from Creative biogene Species Human Accession Q86TP1

Human PRUNE ORF clone (AK315120.1) - CDCB157432 from Creative biogene Species Human

Human PRUNE cDNA Clone(NM_021222.1) - CDFG003292 from Creative biogene Species Human

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