PRUNE

Gene Symbol	PRUNE
Entrez Gene	58497
Alt Symbol	DRES-17, DRES17, HTCD37
Species	Human
Gene Type	protein-coding
Description	prune exopolyphosphatase
Other Description	Drosophila-related expressed sequence 17|protein prune homolog
Swissprots	B2RCH8 Q96JU5 Q5SZF9 B4DFL7 Q9UIV0 Q9C072 Q8N654 Q659E5 Q9C071 Q86TP1 Q6P4E0
Accessions	EAW53485 EAW53486 EAW53487 EAW53488 EAW53489 EAW53490 Q86TP1 AF051907 AAC95290 AF123538 AAK00592 AF123539 AAK00593 AK027875 BAB55423 AK294154 BAG57478 AK298273 BAG60534 AK315120 BAG37575 AK316537 BAH14908 AL122054 CAH56396 AL137324 BC014886 AAH14886 BC017755 BC025304 AAH25304 BC063481 AAH63481 BM554427 DA719664 DA942287 DQ892819 ABM83745 DQ896065 ABM87064 U67085 AAF04914 XM_005245393 XP_005245450 XM_005245397 XP_005245454 XM_011509830 XP_011508132 XM_011509831 XP_011508133 XM_011509832 XP_011508134 NM_001303229 NP_001290158 NM_001303242 NP_001290171 NM_001303243 NP_001290172 NM_021222 NP_067045 NR_130130 NR_130131 NR_130132 NR_130135
Function	Phosphodiesterase (PDE) that has higher activity toward cAMP than cGMP, as substrate. Plays a role in cell proliferation, is able to induce cell motility and acts as a negative regulator of NME1. {ECO:0000269|PubMed:10602478, ECO:0000269|PubMed:11687967, ECO:0000269|PubMed:14998490, ECO:0000269|PubMed:16428445, ECO:0000269|PubMed:17906697}.
Subcellular Location	Cytoplasm. Nucleus. Cell junction, focal adhesion. Note=In some transfected cells a nuclear staining is also observed.
Tissue Specificity	Ubiquitously expressed. Seems to be overexpressed in aggressive sarcoma subtypes, such as leiomyosarcomas and malignant fibrous histiocytomas (MFH) as well as in the less malignant liposarcomas. {ECO:0000269|PubMed:10602478, ECO:0000269|PubMed:11687967, ECO:0000269|PubMed:15671547}.
Top Pathways	Purine metabolism

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

PRUNE 293T Cell Transient Overexpression Lysate(Denatured) - H00058497-T01 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

PRUNE overexpression lysate - LY402855 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

PRUNE 293 Cell Lysate - 402486 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg Species Drosophila

PRUNE Overexpression Lysate (Denatured) - H00058497-T01 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

PRUNE Overexpression Lysate (Native) - NBL1-14852 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

PRUNE Over-expression Lysate Product - GWB-605CE2 from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

Panoply™ Human PRUNE Knockdown Stable Cell Line - CSC-DC012547 from Creative biogene Category Cell Line Species Human

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