PRUNE

Gene Symbol	PRUNE
Entrez Gene	58497
Alt Symbol	DRES-17, DRES17, HTCD37
Species	Human
Gene Type	protein-coding
Description	prune exopolyphosphatase
Other Description	Drosophila-related expressed sequence 17|protein prune homolog
Swissprots	B2RCH8 Q96JU5 Q5SZF9 B4DFL7 Q9UIV0 Q9C072 Q8N654 Q659E5 Q9C071 Q86TP1 Q6P4E0
Accessions	EAW53485 EAW53486 EAW53487 EAW53488 EAW53489 EAW53490 Q86TP1 AF051907 AAC95290 AF123538 AAK00592 AF123539 AAK00593 AK027875 BAB55423 AK294154 BAG57478 AK298273 BAG60534 AK315120 BAG37575 AK316537 BAH14908 AL122054 CAH56396 AL137324 BC014886 AAH14886 BC017755 BC025304 AAH25304 BC063481 AAH63481 BM554427 DA719664 DA942287 DQ892819 ABM83745 DQ896065 ABM87064 U67085 AAF04914 XM_005245393 XP_005245450 XM_005245397 XP_005245454 XM_011509830 XP_011508132 XM_011509831 XP_011508133 XM_011509832 XP_011508134 NM_001303229 NP_001290158 NM_001303242 NP_001290171 NM_001303243 NP_001290172 NM_021222 NP_067045 NR_130130 NR_130131 NR_130132 NR_130135
Function	Phosphodiesterase (PDE) that has higher activity toward cAMP than cGMP, as substrate. Plays a role in cell proliferation, is able to induce cell motility and acts as a negative regulator of NME1. {ECO:0000269|PubMed:10602478, ECO:0000269|PubMed:11687967, ECO:0000269|PubMed:14998490, ECO:0000269|PubMed:16428445, ECO:0000269|PubMed:17906697}.
Subcellular Location	Cytoplasm. Nucleus. Cell junction, focal adhesion. Note=In some transfected cells a nuclear staining is also observed.
Tissue Specificity	Ubiquitously expressed. Seems to be overexpressed in aggressive sarcoma subtypes, such as leiomyosarcomas and malignant fibrous histiocytomas (MFH) as well as in the less malignant liposarcomas. {ECO:0000269|PubMed:10602478, ECO:0000269|PubMed:11687967, ECO:0000269|PubMed:15671547}.
Top Pathways	Purine metabolism

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human PRUNE full length protein - ab153466 from Abcam Category Protein Source Wheat germ Species Human

PRUNE Antibody Blocking Peptide - LS-E10296 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human PRUNE Protein - H00058497-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

PRUNE-Antibody-C-term-Blocking-Peptide - BP9748b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Human PRUNE protein - orb244871 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

PRUNE - H00058497-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

PRUNE - H00058497-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

PRUNE fusion protein - Ag13275 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

Recombinant Human PRUNE, His-tagged - PRUNE-1997H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human Protein prune homolog(PRUNE) - CSB-YP771430HU CSB-BP771430HU CSB-MP771430HU from Cusabio Category Protein Source Yeast or Baculovirus or Mammalian cell Species Human

Recombinant human Protein prune homolog - CSB-EP771430HU from Cusabio Category Protein Source E.coli Species Human

PRUNE Recombinant Protein Antigen - NBP1-84055PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

PRUNE-Antibody-C-term-Blocking-Peptide - BP9809b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PRUNE Peptide, Human - M34GP12547H from Creative Peptides Category Peptide Source Synthetic. Species Human

Prune homolog, Recombinant Protein - MBS1461502 from MyBioSource Category Protein Prices $190.00, $460.00, $750.00, $1,180.00, $1,235.00, $1,455.00, $1,455.00, $2,005.00, $2,470.00, $2,470.00 Sizes 50 µg (E-Coli), 200 µg (E-Coli), 500 µg (E-Coli), 1 mg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell

Recombinant Human PRUNE Protein (1-168 aa), His-tagged - PRUNE-1055H from Creative Biomart Category Protein Source E. coli Species Human

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