HIF1AN

Gene Symbol	HIF1AN
Entrez Gene	55662
Alt Symbol	FIH1
Species	Human
Gene Type	protein-coding
Description	hypoxia inducible factor 1, alpha subunit inhibitor
Other Description	FIH-1|factor inhibiting HIF-1|factor inhibiting HIF1|hypoxia-inducible factor 1-alpha inhibitor|hypoxia-inducible factor asparagine hydroxylase|peptide-aspartate beta-dioxygenase
Swissprots	Q969Q7 D3DR69 Q9NPV5 Q9NWT6 Q5W147
Accessions	CDM55393 CDM55574 EAW49817 EAW49818 Q9NWT6 AF395830 AAL27308 AK000622 BAA91291 AK025680 BAB15213 AK295353 BAG58320 AL359615 CAB94885 AW015561 BC007719 AAH07719 BC015574 DQ892767 ABM83693 DQ896013 ABM87012 XM_011539940 XP_011538242 XM_011539941 XP_011538243 NM_017902 NP_060372
Function	Hydroxylates HIF-1 alpha at 'Asp-803' in the C-terminal transactivation domain (CAD). Functions as an oxygen sensor and, under normoxic conditions, the hydroxylation prevents interaction of HIF-1 with transcriptional coactivators including Cbp/p300- interacting transactivator. Involved in transcriptional repression through interaction with HIF1A, VHL and histone deacetylases. Hydroxylates specific Asn residues within ankyrin repeat domains (ARD) of NFKB1, NFKBIA, NOTCH1, ASB4, PPP1R12A and several other ARD-containing proteins. Also hydroxylates Asp and His residues within ARDs of ANK1 and TNKS2, respectively. Negatively regulates NOTCH1 activity, accelerating myogenic differentiation. Positively regulates ASB4 activity, promoting vascular differentiation. {ECO:0000269|PubMed:12042299, ECO:0000269|PubMed:12080085, ECO:0000269|PubMed:17003112, ECO:0000269|PubMed:17573339, ECO:0000269|PubMed:18299578, ECO:0000269|PubMed:19245366, ECO:0000269|PubMed:21177872, ECO:0000269|PubMed:21251231}.
Subcellular Location	Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Note=Mainly cytoplasmic localization, but interaction with NOTCH1 results in nuclear localization and interaction with ABPA3 results in perinuclear localization in macrophages.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human HIF1AN ELISA Kit (Sandwich ELISA) - LS-F9923 from LifeSpan Bioscience Category ELISA Kit Prices $720.00 Sizes 1 plate Sensitivity 14.4 pg/ml Range 31.25-2000 pg/ml

Human HIF1aN ELISA Kit - abx151809 from Abbexa Category ELISA Kit Sensitivity 14.4 pg/ml Range 31.25 pg/ml - 2000 pg/ml

Hypoxia-inducible factor 1-alpha inhibitor, HIF1AN, Human, ELISA Kit - E0495h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t Range 0.312-20 ng/mL

HIF1AN (Human) IP-WB Antibody Pair - H00055662-PW1 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

Hypoxia Inducible Factor 1 Alpha Subunit Inhibitor (HIF1aN), ELISA Kit - MBS2025164 from MyBioSource Category ELISA Kit Prices $380.00, $565.00, $765.00, $3,130.00, $5,670.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity Typically less than 14.4pg/mL. Range 31.25-2000pg/mL

ELISA Kit for Hypoxia Inducible Factor 1 Alpha Subunit Inhibitor (HIF1aN) - SEG323Hu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 14.4pg/mL. Range 31.25-2000pg/mL The standard curve concentrations used for the ELISA’s were 2000pg/mL, 1000pg/mL, 500pg/mL, 250pg/mL, 125pg/mL, 62.5pg/mL, 31.25pg/mL

ELISA Kit for Hypoxia Inducible Factor 1 Alpha Subunit Inhibitor (HIF1aN) - SEG323Hu from Cloud-clone Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 14.4pg/mL. Range 31.25-2000pg/mL The standard curve concentrations used for the ELISA's were 2000pg/mL, 1000pg/mL, 500pg/mL, 250pg/mL, 125pg/mL, 62.5pg/mL, 31.25pg/mL

Human HIF1AN ELISA Kit (Custom ELISA) - LS-F14643 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 31.25-2000 pg/ml

Mouse HIF1AN ELISA Kit (Custom ELISA) - LS-F14644 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 31.25-2000 pg/ml

Human Hypoxia-inducible factor 1-alpha inhibitor ELISA Kit - abx253877 from Abbexa Category ELISA Kit Range 0.312 ng/ml - 20 ng/ml

Human Hypoxia-inducible factor 1-alpha inhibitor ELISA Kit - EKE53041 from Biomatik Category ELISA Kit Prices $685.40, $2,912.95, $5,483.20 Sizes 96 t, 5x96t, 10x96t Sensitivity The minimum detectable dose of this kit is typically less than 0.12 ng/mL Range 0.312-20 ng/mL

Human Hypoxia-inducible factor 1-alpha inhibitor (HIF1AN) ELISA Kit - EKA01380 from Biomatik Category ELISA Kit Prices $732.00 Sizes 96 t Sensitivity 14.4 pg/mL Range 31.25-2000 pg/mL

HIF1AN - EKH1842 from Nordic BioSite Sensitivity 0.188ng/ml Range 0.312-20ng/ml

Human HIF1AN ELISA Kit - E019184 from Biobool Category ELISA Kit Sensitivity Typically less than 14.4pg/mL.

HIF1AN ELISA Kit (Human) (OKEH04329) - OKEH04329 from Aviva Systems Biology Category ELISA Kit Prices $596.00 Sizes 96 wells Sensitivity < 0.15 ng/mL Range 0.31 - 20 ng/mL

Human Hypoxia-inducible factor 1-alpha inhibitor ELISA Kit - EK1840 from Signalway Antibody Category ELISA Kit Prices $599.00 Sizes 1x96t Sensitivity less than 0.12ng/mL Range 0.312-20 ng/mL

anti-HIF1AN antibody - ARG56304 from Arigo Biolaboratories Category ELISA Kit

Hypoxia Inducible Factor 1 Alpha Inhibitor (HIF1AN), ELISA Kit - MBS9392095 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Hypoxia Inducible Factor 1 Alpha Inhibitor (HIF1AN), ELISA Kit - MBS9392103 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Hypoxia Inducible Factor 1 Alpha Inhibitor (HIF1AN), ELISA Kit - MBS9392088 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Hypoxia Inducible Factor 1 Alpha Inhibitor (HIF1AN), ELISA Kit - MBS9392091 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Hypoxia Inducible Factor 1 Alpha Inhibitor (HIF1AN), ELISA Kit - MBS9392089 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Hypoxia Inducible Factor 1 Alpha Inhibitor (HIF1AN), ELISA Kit - MBS9392090 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Hypoxia Inducible Factor 1 Alpha Inhibitor (HIF1AN), ELISA Kit - MBS9392094 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Hypoxia Inducible Factor 1 Alpha Inhibitor (HIF1AN), ELISA Kit - MBS9392099 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

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