HIF1AN
| Gene Symbol | HIF1AN |
|---|---|
| Entrez Gene | 55662 |
| Alt Symbol | FIH1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | hypoxia inducible factor 1, alpha subunit inhibitor |
| Other Description | FIH-1|factor inhibiting HIF-1|factor inhibiting HIF1|hypoxia-inducible factor 1-alpha inhibitor|hypoxia-inducible factor asparagine hydroxylase|peptide-aspartate beta-dioxygenase |
| Swissprots | Q969Q7 D3DR69 Q9NPV5 Q9NWT6 Q5W147 |
| Accessions | CDM55393 CDM55574 EAW49817 EAW49818 Q9NWT6 AF395830 AAL27308 AK000622 BAA91291 AK025680 BAB15213 AK295353 BAG58320 AL359615 CAB94885 AW015561 BC007719 AAH07719 BC015574 DQ892767 ABM83693 DQ896013 ABM87012 XM_011539940 XP_011538242 XM_011539941 XP_011538243 NM_017902 NP_060372 |
| Function | Hydroxylates HIF-1 alpha at 'Asp-803' in the C-terminal transactivation domain (CAD). Functions as an oxygen sensor and, under normoxic conditions, the hydroxylation prevents interaction of HIF-1 with transcriptional coactivators including Cbp/p300- interacting transactivator. Involved in transcriptional repression through interaction with HIF1A, VHL and histone deacetylases. Hydroxylates specific Asn residues within ankyrin repeat domains (ARD) of NFKB1, NFKBIA, NOTCH1, ASB4, PPP1R12A and several other ARD-containing proteins. Also hydroxylates Asp and His residues within ARDs of ANK1 and TNKS2, respectively. Negatively regulates NOTCH1 activity, accelerating myogenic differentiation. Positively regulates ASB4 activity, promoting vascular differentiation. {ECO:0000269|PubMed:12042299, ECO:0000269|PubMed:12080085, ECO:0000269|PubMed:17003112, ECO:0000269|PubMed:17573339, ECO:0000269|PubMed:18299578, ECO:0000269|PubMed:19245366, ECO:0000269|PubMed:21177872, ECO:0000269|PubMed:21251231}. |
| Subcellular Location | Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Note=Mainly cytoplasmic localization, but interaction with NOTCH1 results in nuclear localization and interaction with ABPA3 results in perinuclear localization in macrophages. |
FIH-1 CRISPR/Cas9 KO Plasmid (h) - sc-402511 from Santa Cruz Biotechnology
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FIH-1 HDR Plasmid (h) - sc-402511-HDR from Santa Cruz Biotechnology
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FIH-1 Double Nickase Plasmid (h) - sc-402511-NIC from Santa Cruz Biotechnology
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FIH-1 Double Nickase Plasmid (h2) - sc-402511-NIC-2 from Santa Cruz Biotechnology
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FIH-1 CRISPR Activation Plasmid (h) - sc-402511-ACT from Santa Cruz Biotechnology
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FIH-1 CRISPR Activation Plasmid (h2) - sc-402511-ACT-2 from Santa Cruz Biotechnology
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FIH-1 Lentiviral Activation Particles (h) - sc-402511-LAC from Santa Cruz Biotechnology
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FIH-1 Lentiviral Activation Particles (h2) - sc-402511-LAC-2 from Santa Cruz Biotechnology
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FIH-1 siRNA (h) - sc-37885 from Santa Cruz Biotechnology
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FIH-1 shRNA Plasmid (h) - sc-37885-SH from Santa Cruz Biotechnology
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FIH-1 shRNA (h) Lentiviral Particles - sc-37885-V from Santa Cruz Biotechnology
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FIH-1/HIF-1AN RNAi - H00055662-R01 from Novus Biologicals
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MISSION® esiRNA - EHU031751 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN10031 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10031 from Sigma-Aldrich
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HIF1AN siRNA (Human) - CRJ0814 from Cohesion Biosciences
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HIF1AN - MBS8218361 from MyBioSource
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shRNA set against Human HIF1AN (NM_017902.2) - SHH312129 from Creative biogene
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shRNA set against Human HIF1AN(NM_017902.2) - SHH120593 from Creative biogene
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Human HIF1AN siRNA - orb271315 from Biorbyt
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HIF1AN shRNA Plasmid (Human) - CHJ0814 from Cohesion Biosciences
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HIF1AN miRNA 3'UTR clone - MiUTR1H-04499 from Creative biogene
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